Adverse effects of a substance that result either from a single exposure
Acute toxicity describes the adverse effects of a substance that result either from a single exposure[1] or from multiple exposures in a short period of time (usually less than 24 hours). [2] To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.[2]
Acute toxicity is distinguished from chronic toxicity, which describes the adverse health effects from repeated exposures, often at lower levels, to a substance over a longer time period (months or years).
It is widely considered unethical to use humans as test subjects for acute (or chronic) toxicity research. However, some information can be gained from investigating accidental human exposures (e.g., factory accidents). Otherwise, most acute toxicity data comes from animal testing or, more recently, in vitro testing methods and inference from data on similar substances.[1][3]
^ ab"The MSDS HyperGlossary: Acute toxicity". Safety Emporium. Archived from the original on 16 October 2006. Retrieved 2006-11-15.
^ abIUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version: (2006–) "acute toxicity". doi:10.1351/goldbook.AT06800
^Walum E (1998). "Acute oral toxicity". Environ. Health Perspect. 106 (Suppl 2). Environmental Health Perspectives, Vol. 106: 497–503. doi:10.2307/3433801. JSTOR 3433801. PMC 1533392. PMID 9599698.
Acutetoxicity describes the adverse effects of a substance that result either from a single exposure or from multiple exposures in a short period of time...
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on...
severe toxicity hemodialysis is recommended. The risk of death is generally low. Acutetoxicity generally has better outcomes than chronic toxicity. In the...
poisoning typically occurs from ingestion of excess iron that results in acutetoxicity. Mild symptoms which occur within hours include vomiting, diarrhea,...
toxicity is in contrast to acutetoxicity, which occurs over a shorter period of time to higher concentrations. Various toxicity tests can be performed to...
established four Toxicity Categories for acute hazards of pesticide products, with "Category I" being the highest toxicity category (toxicity class). Most...
international government-related or -sponsored organization. It addresses the acutetoxicity of agents such as soil fumigants, fungicides, herbicides, insecticides...
more toxic when consumed orally. The acutetoxicity, although more lethal, is less common than sub-lethal toxicity or cumulative effects. Field exposure...
"Identification and Characterization of Toxicity of Contaminants in Pet Food Leading to an Outbreak of Renal Toxicity in Cats and Dogs". Toxicological Sciences...
bee mortality observed in southern France was related to acute fipronil toxicity. Toxicity was linked to defective seed treatment, which generated dust...
that contribute to acutetoxicity, skin corrosion or serious eye damage, germ cell mutagenicity, carcinogenicity, reproductive toxicity, skin or respiratory...
used as a general indicator of a substance's acutetoxicity. A lower LD50 is indicative of higher toxicity. The term LD50 is generally attributed to John...
(particularly pollinators), birds, fish, and eventually humans. The issue of toxicity was complicated, partly because DDT's effects varied from species to species...
Fish acutetoxicity syndrome (FATS) is a set of common chemical and functional responses in fish resulting from a short-term, acute exposure to a lethal...
and of recent onset. Acutetoxicity, the adverse effects of a substance from a single exposure or in a short period of time Acutance, in photography, subjective...
and their effect on someone with HIV". Wood R (19 April 1988). "The AcuteToxicity of Nitrite Inhalants". Nida Research Monograph. 83: 28–38. PMID 3140020...
hazardous to humans (Class II) by the World Health Organization based on acutetoxicity information dating to 1999. Exposure surpassing recommended levels has...
Oral Toxicity: A liquid or solid with an LD50 for acute oral toxicity of not more than 300 mg/kg. Dermal Toxicity. A material with an LD50 for acute dermal...
Some potential effects of diafenthiuron include: Acutetoxicity: diafenthiuron can be highly toxic, especially to invertebrates such as crustaceans and...
environments. Common tests include standardized acute and chronic toxicity tests lasting 24–96 hours (acute test) to 7 days or more (chronic tests). These...
well as other wrestlers of that period. She died as a result of an acutetoxicity on May 1, 2003, in the home she shared with wrestler Lex Luger. Hulette...
any toxicity appears. Human toxicity is, however, hard to avoid with pesticides targeting mammals, such as rodenticides. The risk from toxicity is also...
banned for poultry use in the United States in 2005. It is unlikely that an acute overdose of either compound would result in symptoms more serious than either...
(amsacrine). Dimethylacetamide, like most simple alkyl amides, is of low acutetoxicity. Chronic exposure can cause hepatotoxicity. At high doses (400 mg/kg...
initial increases in locomotor activity. Even in comparison with acutetoxicity, chronic toxicity is poorly researched. Only the post-mortem study did little...
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