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Acetone carboxylase information


Acetone carboxylase
Identifiers
EC no.6.4.1.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an acetone carboxylase (EC 6.4.1.6) is an enzyme that catalyzes the chemical reaction

acetone + CO2 + ATP + 2 H2O acetoacetate + AMP + 2 phosphate

The 4 substrates of this enzyme are acetone, CO2, ATP, and H2O, whereas its 3 products are acetoacetate, AMP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is acetone:carbon-dioxide ligase (AMP-forming).

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Acetone carboxylase

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In enzymology, an acetone carboxylase (EC 6.4.1.6) is an enzyme that catalyzes the chemical reaction acetone + CO2 + ATP + 2 H2O ⇌ {\displaystyle \rightleftharpoons...

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Ketogenesis

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lipogenesis, promotes fatty acid oxidation, switches off acetyl-CoA carboxylase, turns on malonyl-CoA decarboxylase, and consequently induces ketogenesis...

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Gluconeogenesis

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acetyl-CoA from fatty acids yields ketone bodies, including acetone, and up to ~60% of acetone may be oxidized in the liver to the pyruvate precursors acetol...

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Ketosis

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into ketone bodies: pyruvate, acetoacetate, beta-hydroxybutyrate, and acetone. These ketone bodies can function as an energy source as well as signalling...

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Fatty acid metabolism

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later converted into succinyl-CoA through biotin-dependant propionyl-CoA carboxylase (PCC) and Vitamin B12-dependant methylmalonyl-CoA mutase (MCM), sequentially...

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Active site

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Herbicides Cyclohexanedione Cyclohexanedione targets the Acetyl-CoA carboxylase which is involved in the first step of fat synthesis: ATP-dependent carboxylation...

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Citric acid

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this conversion, and allosterically regulates the enzyme acetyl-CoA carboxylase, which is the regulating enzyme in the conversion of acetyl-CoA into...

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Malonic acid

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Malonyl CoA is formed there from acetyl CoA by the action of acetyl-CoA carboxylase, and the malonate is transferred to an acyl carrier protein to be added...

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Carbon dioxide

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constructed, and oxygen is produced as a by-product. Ribulose-1,5-bisphosphate carboxylase oxygenase, commonly abbreviated to RuBisCO, is the enzyme involved in...

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Ketogenic diet

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contraindicated in the treatment of other diseases such as pyruvate carboxylase deficiency, porphyria, and other rare genetic disorders of fat metabolism...

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Urease

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seeds, and pea seeds have all proven useful sources of urease. Urea carboxylase Allophanate hydrolase Urease test PDB: 2KAU​; Jabri E, Carr MB, Hausinger...

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