ARHGEF1 information

ARHGEF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IAP, 1SHZ, 3AB3, 3ODO, 3ODW, 3ODX, 3P6A
Identifiers
Aliases	ARHGEF1, GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5, Rho guanine nucleotide exchange factor 1, IMD62
External IDs	OMIM: 601855; MGI: 1353510; HomoloGene: 3454; GeneCards: ARHGEF1; OMA:ARHGEF1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,930,150 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,626,019 bp
RNA expression pattern
	Top expressed in
	lymph node; ; upper lobe of left lung; ; right lung; ; spleen; ; right uterine tube; ; cardia; ; monocyte; ; right lobe of thyroid gland; ; left uterine tube; ; body of stomach;
	Top expressed in
	thymus; ; lip; ; yolk sac; ; spleen; ; superior frontal gyrus; ; blood; ; ascending aorta; ; cerebellar cortex; ; internal carotid artery; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; RNA binding; guanyl-nucleotide exchange factor activity; G protein-coupled receptor binding;
Cellular component	plasma membrane; membrane; cytoplasm; cytosol;
Biological process	cell population proliferation; regulation of Rho protein signal transduction; Rho protein signal transduction; positive regulation of GTPase activity; positive regulation of apoptotic process; regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	9138
	16801
	ENSG00000076928
	ENSMUSG00000040940
	Q92888
	Q61210
	NM_004706; NM_198977; NM_199002
	NM_001130150; NM_001130151; NM_001130152; NM_001130153; NM_008488
	NP_004697; NP_945328; NP_945353
	NP_001123622; NP_001123623; NP_001123624; NP_001123625; NP_032514
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.^[5]^[6]^[7] This protein is also called RhoGEF1 or p115-RhoGEF.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076928 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040940 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, et al. (October 1996). "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". The Journal of Biological Chemistry. 271 (41): 25452–8. doi:10.1074/jbc.271.41.25452. PMID 8810315.
^ Aasheim HC, Pedeutour F, Smeland EB (April 1997). "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues". Oncogene. 14 (14): 1747–52. doi:10.1038/sj.onc.1200994. PMID 9135076. S2CID 24528606.
^ "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076928 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040940 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8810315-5] Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, et al. (October 1996). "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". The Journal of Biological Chemistry. 271 (41): 25452–8. doi:10.1074/jbc.271.41.25452. PMID 8810315.

[pmid9135076-6] Aasheim HC, Pedeutour F, Smeland EB (April 1997). "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues". Oncogene. 14 (14): 1747–52. doi:10.1038/sj.onc.1200994. PMID 9135076. S2CID 24528606.

[entrez-7] "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1".

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