AKAP13 information

AKAP13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DRN, 2LG1, 4D0N, 4D0O
Identifiers
Aliases	AKAP13, A kinase (PRKA) anchor protein 13, AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47, A-kinase anchoring protein 13, A-kinase anchor protein 13
External IDs	OMIM: 604686; MGI: 2676556; HomoloGene: 4903; GeneCards: AKAP13; OMA:AKAP13 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	85,749,358 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	75,754,609 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; lower lobe of lung; ; sural nerve; ; visceral pleura; ; pylorus; ; right ventricle; ; vena cava; ; synovial joint; ; myometrium; ; cardia;
	Top expressed in
	blood; ; submandibular gland; ; bone marrow; ; spleen; ; foot; ; extraocular muscle; ; ankle; ; interventricular septum; ; hand; ; semi-lunar valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; MAP-kinase scaffold activity; guanyl-nucleotide exchange factor activity; protein binding; molecular adaptor activity; protein kinase A binding; signal transducer activity; cAMP-dependent protein kinase activity;
Cellular component	membrane; cytosol; actin cytoskeleton; perinuclear region of cytoplasm; nucleus; cell cortex; actin filament; cortical actin cytoskeleton; cytoplasm; intracellular anatomical structure;
Biological process	regulation of cardiac muscle hypertrophy; bone development; intracellular signal transduction; regulation of glucocorticoid mediated signaling pathway; positive regulation of Rho protein signal transduction; regulation of sarcomere organization; positive regulation of I-kappaB kinase/NF-kappaB signaling; adrenergic receptor signaling pathway; regulation of small GTPase mediated signal transduction; adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; heart development; positive regulation of apoptotic process; cardiac muscle cell differentiation; regulation of Rho protein signal transduction; protein phosphorylation; regulation of protein kinase activity; nuclear export; G protein-coupled receptor signaling pathway; positive regulation of MAP kinase activity; cell growth involved in cardiac muscle cell development;
	Sources:Amigo / QuickGO
Orthologs
	11214
	75547
	ENSG00000170776
	ENSMUSG00000066406
	Q12802
	E9Q394
	NM_144767; NM_001270546; NM_006738; NM_007200; NM_032162
	NM_029332
	NP_001257475; NP_006729; NP_009131
	NP_083608
	Wikidata
View/Edit Human	View/Edit Mouse

A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene.^[5]^[6]^[7] This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170776 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066406 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, et al. (May 1998). "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action". Oncogene. 16 (19): 2513–26. doi:10.1038/sj.onc.1201783. PMID 9627117. S2CID 20906586.
^ Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (August 1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". The Journal of Biological Chemistry. 266 (22): 14188–92. doi:10.1016/S0021-9258(18)98665-5. PMID 1860836.
^ "Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170776 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066406 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9627117-5] Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, et al. (May 1998). "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action". Oncogene. 16 (19): 2513–26. doi:10.1038/sj.onc.1201783. PMID 9627117. S2CID 20906586.

[pmid1860836-6] Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (August 1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". The Journal of Biological Chemistry. 266 (22): 14188–92. doi:10.1016/S0021-9258(18)98665-5. PMID 1860836.

[entrez-7] "Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13".

AKAP13 information

and 14 Related for: AKAP13 information

AKAP13

Pleckstrin homology domain

ZNF469

Minor histocompatibility antigen

Stress granule

Estrogen receptor alpha

RhoGEF domain

C1 domain

Louise Wain

PRKAR2A

ARHGEF12

ARHGEF11

ARHGEF1

CTNNAL1