negative regulation of cell population proliferation
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of vascular associated smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell migration
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9510
11504
Ensembl
ENSG00000154734
ENSMUSG00000022893
UniProt
Q9UHI8
P97857
RefSeq (mRNA)
NM_006988
NM_009621
RefSeq (protein)
NP_008919
NP_033751
Location (UCSC)
Chr 21: 26.84 – 26.85 Mb
Chr 16: 85.59 – 85.6 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000154734 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022893 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (September 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
^"Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1".
thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase...
members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include...
the article. ABCG1: encoding ATP-binding cassette sub-family G member 1 ADAMTS1 encoding enzyme a disintegrin and metalloproteinase with thrombospondin...
Vascular endothelial growth factor A has been shown to interact with: ADAMTS1, CTGF, and NRP1, Vascular endothelial growth factor Bevacizumab (or Avastin)...
bFGF and VEGF TIMP and CDAI inhibit cell migration of endothelial cells ADAMTS1 and ADAMTS8 IFN-α, -β and -γ, CXCL10, IL-4, -12 and -18 inhibit cell migration...
production of progesterone and prostaglandins that induce the expression of ADAMTS1 and other proteases, as well as their inhibitors. This will lead to degradation...
phase II clinical trials for the treatment of several types of cancer. ADAMTS1; ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17;...
Stricker BH, de Boer A, Maitland-van der Zee AH (December 2010). "Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial...
Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA (2007). "ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal...
been shown whether full length ADAM15 plays an inhibitory role in vivo. ADAMTS1 and ADAMTS8 inhibit angiogenesis in vitro in two functional angiogenesis...
PMID 11801661. Rodríguez-Manzaneque JC, Westling J, Thai SN, et al. (2002). "ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase...