ABL2 information

ABL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH
Identifiers
Aliases	ABL2, ABLL, ARG, ABL proto-oncogene 2, non-receptor tyrosine kinase
External IDs	OMIM: 164690; MGI: 87860; HomoloGene: 5278; GeneCards: ABL2; OMA:ABL2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	179,229,684 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	156,477,138 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; visceral pleura; ; parietal pleura; ; middle temporal gyrus; ; Brodmann area 23; ; tibia; ; secondary oocyte; ; cerebellar vermis; ; internal globus pallidus; ; amniotic fluid;
	Top expressed in
	secondary oocyte; ; otolith organ; ; utricle; ; hand; ; foot; ; olfactory bulb; ; Region I of hippocampus proper; ; primitive streak; ; lacrimal gland; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; actin monomer binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; metal ion binding; kinase activity; actin filament binding; protein binding; signaling receptor binding; ATP binding; magnesium ion binding; protein tyrosine kinase activity; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; actin cytoskeleton; cytoskeleton;
Biological process	cellular response to retinoic acid; regulation of actin cytoskeleton reorganization; phosphorylation; positive regulation of phospholipase C activity; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of oxidoreductase activity; regulation of cell motility; protein phosphorylation; cell adhesion; regulation of cell population proliferation; positive regulation of neuron projection development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; innate immune response; signal transduction; regulation of autophagy; regulation of endocytosis; regulation of cell adhesion; cell differentiation; negative regulation of Rho protein signal transduction; exploration behavior;
	Sources:Amigo / QuickGO
Orthologs
	27
	11352
	ENSG00000143322
	ENSMUSG00000026596
	P42684
	Q4JIM5
NM_001136000; NM_001136001; NM_001168236; NM_001168237; NM_001168238;
	NM_001168239; NM_005158; NM_007314
	NM_001136104; NM_009595
NP_001129472; NP_001129473; NP_001161708; NP_001161709; NP_001161710;
	NP_001161711; NP_005149; NP_009298
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143322 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026596 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
^ "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143322 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026596 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3787260-5] Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.

[entrez-6] "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".

ABL2 information

and 12 Related for: ABL2 information

ABL2

Tyrosine kinase

SH2 domain

Catalase

Chromosome 1

Imatinib

Immunological synapse

Protein kinase domain

Cortical granule

SORBS2

Tasman Limited

ETV6