40S ribosomal protein S14 information

RPS14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS14, EMTB, S14, ribosomal protein S14
External IDs	OMIM: 130620; MGI: 98107; HomoloGene: 90926; GeneCards: RPS14; OMA:RPS14 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,449,739 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	60,911,618 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; caput epididymis; ; superficial temporal artery; ; skin of hip; ; corpus epididymis; ; mucosa of paranasal sinus; ; nipple; ; urethra; ; human penis; ; tendon of biceps brachii;
	Top expressed in
	medial ganglionic eminence; ; efferent ductule; ; vas deferens; ; condyle; ; transitional epithelium of urinary bladder; ; abdominal wall; ; fossa; ; cervix; ; blastocyst; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	small ribosomal subunit rRNA binding; structural constituent of ribosome; translation regulator activity; protein binding; mRNA 5'-UTR binding; RNA binding;
Cellular component	cytosol; ribosome; membrane; focal adhesion; cytosolic small ribosomal subunit; nucleolus; mitochondrion; extracellular exosome; extracellular matrix; nucleoplasm; postsynaptic density;
Biological process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of SSU-rRNA; viral transcription; negative regulation of transcription by RNA polymerase II; SRP-dependent cotranslational protein targeting to membrane; translational initiation; erythrocyte differentiation; ribosomal small subunit assembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing; protein biosynthesis; regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	6208
	20044
	ENSG00000164587
	ENSMUSG00000024608
	P62263
	P62264
	NM_005617; NM_001025070; NM_001025071; NM_005616
	NM_020600
	NP_001020241; NP_001020242; NP_005608
	NP_065625
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.^[5]^[6]^[7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164587 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024608 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rhoads DD, Dixit A, Roufa DJ (Jan 1987). "Primary structure of human ribosomal protein S14 and the gene that encodes it". Mol Cell Biol. 6 (8): 2774–83. doi:10.1128/mcb.6.8.2774. PMC 367844. PMID 3785212.
^ Diaz JJ, Roufa DJ (Apr 1992). "Fine-structure map of the human ribosomal protein gene RPS14". Mol Cell Biol. 12 (4): 1680–6. doi:10.1128/mcb.12.4.1680. PMC 369611. PMID 1549121.
^ ^a ^b "Entrez Gene: RPS14 ribosomal protein S14".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164587 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024608 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3785212-5] Rhoads DD, Dixit A, Roufa DJ (Jan 1987). "Primary structure of human ribosomal protein S14 and the gene that encodes it". Mol Cell Biol. 6 (8): 2774–83. doi:10.1128/mcb.6.8.2774. PMC 367844. PMID 3785212.

[pmid1549121-6] Diaz JJ, Roufa DJ (Apr 1992). "Fine-structure map of the human ribosomal protein gene RPS14". Mol Cell Biol. 12 (4): 1680–6. doi:10.1128/mcb.12.4.1680. PMC 369611. PMID 1549121.

[entrez-7] "Entrez Gene: RPS14 ribosomal protein S14".

40S ribosomal protein S14 information

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MicroRNA