ZW10 information

ZW10
Identifiers
Aliases	ZW10, HKNTC1AP, zw10 kinetochore protein
External IDs	OMIM: 603954; MGI: 1349478; HomoloGene: 37959; GeneCards: ZW10; OMA:ZW10 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	113,773,735 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	48,990,075 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; ventricular zone; ; secondary oocyte; ; mucosa of ileum; ; gastrocnemius muscle; ; Achilles tendon; ; cartilage tissue; ; skin of leg; ; ganglionic eminence; ; testicle;
	Top expressed in
	gastrula; ; primary oocyte; ; condyle; ; submandibular gland; ; fossa; ; fetal liver hematopoietic progenitor cell; ; primitive streak; ; hair follicle; ; maxillary prominence; ; motor neuron;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	centromeric DNA binding; protein binding;
Cellular component	spindle pole; kinetochore microtubule; endoplasmic reticulum membrane; spindle; chromosome; RZZ complex; Dsl1/NZR complex; chromosome, centromeric region; cytoskeleton; kinetochore; membrane; endoplasmic reticulum; nucleus; cytoplasm; cytosol;
Biological process	Golgi organization; mitotic cell cycle checkpoint signaling; mitotic spindle assembly checkpoint signaling; cell division; endoplasmic reticulum to Golgi vesicle-mediated transport; establishment of mitotic spindle orientation; mitotic sister chromatid segregation; protein transport; cell cycle; mitotic metaphase plate congression; regulation of exit from mitosis; protein localization to kinetochore; vesicle-mediated transport; sister chromatid cohesion; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; meiosis; mitotic cell cycle; transport; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	9183
	26951
	ENSG00000086827
	ENSMUSG00000032264
	O43264
	O54692
	NM_004724
	NM_012039
	NP_004715
	NP_036169
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene.^[5]^[6] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000086827 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Starr DA, Williams BC, Li Z, Etemad-Moghadam B, Dawe RK, Goldberg ML (Oct 1997). "Conservation of the centromere/kinetochore protein ZW10". J Cell Biol. 138 (6): 1289–301. doi:10.1083/jcb.138.6.1289. PMC 2132553. PMID 9298984.
^ ^a ^b "Entrez Gene: ZW10 ZW10, kinetochore associated, homolog (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086827 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032264 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9298984-5] Starr DA, Williams BC, Li Z, Etemad-Moghadam B, Dawe RK, Goldberg ML (Oct 1997). "Conservation of the centromere/kinetochore protein ZW10". J Cell Biol. 138 (6): 1289–301. doi:10.1083/jcb.138.6.1289. PMC 2132553. PMID 9298984.

[entrez-6] "Entrez Gene: ZW10 ZW10, kinetochore associated, homolog (Drosophila)".

ZW10 information

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