In molecular biology, the XPG-I is a protein domain found on Xeroderma Pigmentosum Complementation Group G (XPG) protein.[1] The XPG protein is an endonuclease which repairs DNA damage caused by ultraviolet light (UV light). The XPG protein repairs DNA by a process called, Nucleotide excision repair. Mutations in the protein commonly cause Xeroderma Pigmentosum which often lead to skin cancer.
^O'Donovan A, Scherly D, Clarkson SG, Wood RD (1994). "Isolation of active recombinant XPG protein, a human DNA repair endonuclease". J Biol Chem. 269 (23): 15965–8. doi:10.1016/S0021-9258(17)33956-X. PMID 8206890.
and 17 Related for: XPG I protein domain information
molecular biology, the XPG-I is a proteindomain found on Xeroderma Pigmentosum Complementation Group G (XPG) protein. The XPGprotein is an endonuclease...
biology the proteindomainXPG refers to, in this case, the N-terminus of XPG. The XPGprotein can be corrected by a 133 kDa nuclear protein, XPGC. XPGC...
complex TFIIH, the nucleotide excision repair proteinXPG, and Cockayne syndrome group B (CSB) protein". Biochemistry. 35 (7): 2157–67. doi:10.1021/bi9524124...
complex TFIIH, the nucleotide excision repair proteinXPG, and Cockayne syndrome group B (CSB) protein". Biochemistry. 35 (7): 2157–67. doi:10.1021/bi9524124...
complex TFIIH, the nucleotide excision repair proteinXPG, and Cockayne syndrome group B (CSB) protein". Biochemistry. 35 (7): 2157–67. doi:10.1021/bi9524124...
shown interactions with the C-terminal domain of RNA polymerase II, ribonuclease III, and NER factor Rad2/XPG. Meanwhile, the C-terminus encodes the DNA/RNA...
I. Protein coding genes are transcribed by RNA polymerase II into messenger RNAs (mRNAs) that carry the information from DNA to the site of protein synthesis...
nucleopolyhedrovirus (NPV). Hz2V070 has the most similarity to the xeroderma pigmentosum G (XPG) enzyme, which is related to other enzymes playing roles in nucleotide-excision...
major domains of the protein are conserved among numerous RNA and DNA helicases. Detailed structural analysis of CSB has been performed; motifs I, Ia,...
repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved...
complex TFIIH, the nucleotide excision repair proteinXPG, and Cockayne syndrome group B (CSB) protein". Biochemistry. 35 (7): 2157–67. doi:10.1021/bi9524124...
complex TFIIH, the nucleotide excision repair proteinXPG, and Cockayne syndrome group B (CSB) protein". Biochemistry. 35 (7): 2157–67. doi:10.1021/bi9524124...
complex make the 5' and 3' cuts, respectively. In mammals, the homologs XPG and XPF-ERCC1 affect the same respective nicks. Double-strand breaks, both...
sensitivities of cells defective in the other XP genes XPA, XPB, XPC, XPD, XPF and XPG. As shown by Wittschieben et al., when DDB2 is in a complex with DDB1, forming...
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