WNK1 information

WNK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PWN
Identifiers
Aliases	WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1
External IDs	OMIM: 605232; MGI: 2442092; HomoloGene: 14253; GeneCards: WNK1; OMA:WNK1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	911,452 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	120,038,672 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; external globus pallidus; ; optic nerve; ; trabecular bone; ; inferior olivary nucleus; ; ventral tegmental area; ; superior vestibular nucleus; ; right ventricle;
	Top expressed in
	right lung lobe; ; saccule; ; myocardium of ventricle; ; ciliary body; ; knee joint; ; secondary oocyte; ; body of femur; ; pineal gland; ; medullary collecting duct; ; facial motor nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase inhibitor activity; transferase activity; nucleotide binding; potassium channel inhibitor activity; phosphatase binding; protein kinase inhibitor activity; kinase activity; protein binding; chloride channel inhibitor activity; magnesium ion binding; protein serine/threonine kinase activity; ATP binding; protein kinase activity; protein kinase binding; protein kinase activator activity;
Cellular component	cytoplasm; cytosol; membrane;
Biological process	phosphorylation; negative regulation of phosphatase activity; neuron development; positive regulation of systemic arterial blood pressure; protein autophosphorylation; negative regulation of protein serine/threonine kinase activity; peptidyl-threonine phosphorylation; negative regulation of pancreatic juice secretion; negative regulation of kinase activity; regulation of cellular process; ion transport; intracellular signal transduction; negative regulation of protein kinase activity; regulation of sodium ion transport; protein phosphorylation; negative regulation of sodium ion transport; activation of protein kinase activity; cellular response to calcium ion; positive regulation of canonical Wnt signaling pathway; positive regulation of T cell chemotaxis; peptidyl-serine phosphorylation; positive regulation of ion transmembrane transporter activity; negative regulation of cell-cell adhesion mediated by integrin; negative regulation of heterotypic cell-cell adhesion; negative regulation of GTPase activity; chemokine (C-C motif) ligand 21 signaling pathway; ion homeostasis; T cell receptor signaling pathway; lymphocyte migration into lymph node; negative regulation of leukocyte cell-cell adhesion; positive regulation of potassium ion import across plasma membrane; cellular response to chemokine; positive regulation of sodium ion transmembrane transporter activity;
	Sources:Amigo / QuickGO
Orthologs
	65125
	232341
	ENSG00000060237
	ENSMUSG00000045962
	Q9H4A3
	P83741
	NM_001184985; NM_014823; NM_018979; NM_213655
NM_001037155; NM_001185020; NM_001185021; NM_001199083; NM_001199084;
	NM_198703
	NP_001171914; NP_055638; NP_061852; NP_998820
	NP_001171949; NP_001171950; NP_001186012; NP_001186013; NP_941992
	Wikidata
View/Edit Human	View/Edit Mouse

WNK (lysine deficient protein kinase 1), also known as WNK1, is an enzyme that is encoded by the WNK1 gene.^[5]^[6]^[7]^[8]^[9] WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family.^[5]^[6]^[7]^[9] The predominant role of WNK1 is the regulation of cation-Cl⁻ cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1) located within the kidney.^[5]^[6]^[9] CCCs mediate ion homeostasis and modulate blood pressure by transporting ions in and out of the cell.^[5] WNK1 mutations as a result have been implicated in blood pressure disorders/diseases; a prime example being familial hyperkalemic hypertension (FHHt).^[5]^[6]^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000060237 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045962 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d ^e Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (February 2017). "WNK Kinase Signaling in Ion Homeostasis and Human Disease". Cell Metabolism. 25 (2): 285–299. doi:10.1016/j.cmet.2017.01.007. hdl:10871/33390. PMID 28178566.
^ ^a ^b ^c ^d Hadchouel J, Ellison DH, Gamba G (2016). "Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases". Annual Review of Physiology. 78: 367–89. doi:10.1146/annurev-physiol-021115-105431. PMID 26863326.
^ ^a ^b ^c Bazúa-Valenti S, Gamba G (May 2015). "Revisiting the NaCl cotransporter regulation by with-no-lysine kinases". American Journal of Physiology. Cell Physiology. 308 (10): C779-91. doi:10.1152/ajpcell.00065.2015. PMC 4436992. PMID 25788573.
^ ^a ^b Cite error: The named reference Xu_2005 was invoked but never defined (see the help page).
^ ^a ^b ^c ^d Huang CL, Cheng CJ (November 2015). "A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter". Pflügers Archiv. 467 (11): 2235–41. doi:10.1007/s00424-015-1708-2. PMC 4601926. PMID 25904388.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000060237 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045962 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Shekarabi_2017-5] Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT (February 2017). "WNK Kinase Signaling in Ion Homeostasis and Human Disease". Cell Metabolism. 25 (2): 285–299. doi:10.1016/j.cmet.2017.01.007. hdl:10871/33390. PMID 28178566.

[Hadchouel_2016-6] Hadchouel J, Ellison DH, Gamba G (2016). "Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases". Annual Review of Physiology. 78: 367–89. doi:10.1146/annurev-physiol-021115-105431. PMID 26863326.

[Bazúa-Valenti_2015-7] Bazúa-Valenti S, Gamba G (May 2015). "Revisiting the NaCl cotransporter regulation by with-no-lysine kinases". American Journal of Physiology. Cell Physiology. 308 (10): C779-91. doi:10.1152/ajpcell.00065.2015. PMC 4436992. PMID 25788573.

[Xu_2005-8] Cite error: The named reference Xu_2005 was invoked but never defined (see the help page).

[Huang_2015-9] Huang CL, Cheng CJ (November 2015). "A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter". Pflügers Archiv. 467 (11): 2235–41. doi:10.1007/s00424-015-1708-2. PMC 4601926. PMID 25904388.

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