LINGO1 information

LINGO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ID5, 4OQT
Identifiers
Aliases	LINGO1, LERN1, LRRN6A, UNQ201, leucine rich repeat and Ig domain containing 1, MRT64
External IDs	OMIM: 609791; MGI: 1915522; HomoloGene: 41891; GeneCards: LINGO1; OMA:LINGO1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	77,820,900 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	56,703,752 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; occipital lobe; ; lateral nuclear group of thalamus; ; amygdala; ; primary visual cortex;
	Top expressed in
	visual cortex; ; primary motor cortex; ; primary visual cortex; ; piriform cortex; ; superior frontal gyrus; ; cingulate gyrus; ; subiculum; ; anterior amygdaloid area; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; epidermal growth factor receptor binding;
Cellular component	membrane; integral component of membrane; plasma membrane; extracellular space; extracellular matrix;
Biological process	negative regulation of axonogenesis; signal transduction; axonogenesis;
	Sources:Amigo / QuickGO
Orthologs
	84894
	235402
	ENSG00000169783
	ENSMUSG00000049556
	Q96FE5
	Q9D1T0
NM_001301186; NM_001301187; NM_001301189; NM_001301191; NM_001301192;
	NM_001301194; NM_001301195; NM_001301197; NM_001301198; NM_001301199; NM_001301200; NM_032808
NM_181074; NM_001311076; NM_001361115; NM_001361116; NM_001361117;
	NM_001361118; NM_001361119; NM_001361120
NP_001288115; NP_001288116; NP_001288118; NP_001288120; NP_001288121;
	NP_001288123; NP_001288124; NP_001288126; NP_001288127; NP_001288128; NP_001288129; NP_116197
NP_001298005; NP_851419; NP_001348044; NP_001348045; NP_001348046;
	NP_001348047; NP_001348048; NP_001348049
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine rich repeat and Immunoglobin-like domain-containing protein 1^[5] also known as LINGO-1 is a protein which is encoded by the LINGO1 gene in humans.^[6]^[7] It belongs to the family of leucine-rich repeat proteins which are known for playing key roles^[8] in the biology of the central nervous system. LINGO-1 is a functional component of the Nogo (neurite outgrowth inhibitor) receptor also known as the reticulon 4 receptor.

It has been suggested that LINGO-1 antagonists such as BIIB033^[9] could significantly improve and regulate survival after neural injury caused by the protein.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169783 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049556 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "LINGO1 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 - LINGO1 gene & protein". UniProt. Retrieved 2015-10-17.
^ "LINGO1 leucine rich repeat and Ig domain containing 1". Entrez Gene.
^ Carim-Todd L, Escarceller M, Estivill X, Sumoy L (Dec 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1) a novel gene with enriched expression in limbic system and neocortex". The European Journal of Neuroscience. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891. S2CID 42086715.
^ de Wit J, Hong W, Luo L, Ghosh A (Jul 2011). "Role of leucine-rich repeat proteins in the development and function of neural circuits" (PDF). Annual Review of Cell and Developmental Biology. 27: 697–729. doi:10.1146/annurev-cellbio-092910-154111. PMID 21740233. Archived from the original (PDF) on 2016-03-04. Retrieved 2015-10-17.
^ "BIIB033". Multiple Sclerosis Discovery Forum. Retrieved 2015-10-18.
^ Agúndez JA, Jiménez-Jimenez FJ, Alonso-Navarro H, García-Martín E (2015). "The potential of LINGO-1 as a therapeutic target for essential tremor". Expert Opin. Ther. Targets. 19 (8): 1139–48. doi:10.1517/14728222.2015.1028360. PMID 25862159. S2CID 24576296.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169783 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049556 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "LINGO1 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 - LINGO1 gene & protein". UniProt. Retrieved 2015-10-17.

[entrez-6] "LINGO1 leucine rich repeat and Ig domain containing 1". Entrez Gene.

[pmid14686891-7] Carim-Todd L, Escarceller M, Estivill X, Sumoy L (Dec 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1) a novel gene with enriched expression in limbic system and neocortex". The European Journal of Neuroscience. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891. S2CID 42086715.

[8] Wit J, Hong W, Luo L, Ghosh A (Jul 2011). "Role of leucine-rich repeat proteins in the development and function of neural circuits" (PDF). Annual Review of Cell and Developmental Biology. 27: 697–729. doi:10.1146/annurev-cellbio-092910-154111. PMID 21740233. Archived from the original (PDF) on 2016-03-04. Retrieved 2015-10-17.

[BIIB033-9] "BIIB033". Multiple Sclerosis Discovery Forum. Retrieved 2015-10-18.

[pmid25862159-10] Agúndez JA, Jiménez-Jimenez FJ, Alonso-Navarro H, García-Martín E (2015). "The potential of LINGO-1 as a therapeutic target for essential tremor". Expert Opin. Ther. Targets. 19 (8): 1139–48. doi:10.1517/14728222.2015.1028360. PMID 25862159. S2CID 24576296.

LINGO1 information

and 8 Related for: LINGO1 information

LINGO1

Essential tremor

BIIB033

Neuroregeneration

Remyelination

LRRN3

Transforming protein RhoA

LINGO2