The Visible Embryo Project (VEP) is a multi-institutional, multidisciplinary research project originally created in the early 1990s as a collaboration between the Developmental Anatomy Center at the National Museum of Health and Medicine and the Biomedical Visualization Laboratory (BVL) at the University of Illinois at Chicago, "to develop software strategies for the development of distributed biostructural databases using cutting-edge technologies for high-performance computing and communications (HPCC), and to implement these tools in the creation of a large-scale digital archive of multidimensional data on normal and abnormal human development."[1] This project related to BVL's other research in the areas of health informatics, educational multimedia, and biomedical imaging science.[2][3][4] Over the following decades, the list of VEP collaborators grew to include over a dozen universities, national laboratories, and companies around the world.
An early (1993) goal of the project was to enable what it called "Spatial Genomics," to create tools and systems for three-dimensional morphological mapping of gene expression, to correlate data from the Human Genome Project with the multidimensional location of genomic expression activity within the morphological context of organisms. This led to the invention in the late 1990s by VEP collaborators of the first system for Spatial transcriptomics.[5][6][7] Other areas that VEP researchers pioneered include early web technologies, cloud computing, blockchain, and virtual assistant technology.
^Doyle, Michael D.; Ang, Cheong; Raju, Rakesh; Klein, Gary; Williams, Betsey S.; DeFanti, Thomas; Goshtasby, Ardeshir; Grzesczuk, Robert; Noe, Adrianne (1993). "Processing of cross-sectional image data for reconstruction of human developmental anatomy from museum specimens". ACM SIGBIO Newsletter. 13 (1). Association for Computing Machinery (ACM): 9–15. doi:10.1145/163424.163426. ISSN 0163-5697. S2CID 1901140.
^Doyle, M. (1991). "The Metamap Process: A New Approach To The Creation Of Object Oriented Image Databases For Medical Education". Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991. IEEE. pp. 1046–1047. doi:10.1109/iembs.1991.684333. ISBN 0-7803-0216-8.
^Carlbom, Ingrid; Hsu, William M.; Klinker, Gudrun; Szeliski, Richard; Waters, Keith; Doyle, Michael; Gettys, Jim; Harris, Kristen M.; Levergood, Thomas M.; Palmer, Ricky; Palmer, Larry; Picart, Marc; Terzopoulos, Demetri; Tonnesen, David; Vannier, Michael; Wallace, Greg (1992). "Modeling and analysis of empirical data in collaborative environments". Communications of the ACM. 35 (6). Association for Computing Machinery (ACM): 74–84. doi:10.1145/129888.129893. ISSN 0001-0782. S2CID 27152196.
^Doyle, M.; Majumbar, S. (1991). "The Use Of Fractal Analysis in the Screening Of Medical/dental X- Ray And Tomographic Images For Early Signs Of Osteoporosis". Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991. IEEE. pp. 2234–2235. doi:10.1109/iembs.1991.684978. ISBN 0-7803-0216-8.
^Doyle MD, Noe A, Michaels GS (2000). "Visible Embryo Project: A platform for spatial genomics". In Oliver WR (ed.). 28th AIPR Workshop: 3D Visualization for Data Exploration and Decision Making. Vol. 3905. p. 248. Bibcode:2000SPIE.3905..248D. doi:10.1117/12.384880. S2CID 85027703. {{cite book}}: |journal= ignored (help)
^US 7613571, Doyle, Michael D.; Pescitelli, Jr., Maurice J. & Williams, Betsey S. et al., "Method and system for the multidimensional morphological reconstruction of genome expression activity", published 2009-11-03
^Al-Janabi A (October 2023). "Decoding the Mechanisms of Embryo Development with Spatial Biology". BioTechniques. 75 (5): 179–182. doi:10.2144/btn-2023-0093.
and 24 Related for: Visible Embryo Project information
The VisibleEmbryoProject (VEP) is a multi-institutional, multidisciplinary research project originally created in the early 1990s as a collaboration...
and George Michaels (of George Mason University), as part of the VisibleEmbryoProject It was later expanded upon in 2016 by Jonas Frisén, Joakim Lundeberg...
An embryo is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of...
patents for work done there by Eolas' co-founders, as part of the VisibleEmbryoProject. The company was founded in 1994 by Dr. Michael Doyle, Rachelle...
recapitulates phylogeny"—is an historical hypothesis that the development of the embryo of an animal, from fertilization to gestation or hatching (ontogeny), goes...
will impact an embryo is dependent on several factors, such as how long the embryo has been exposed, the stage of development the embryo was in when exposed...
The primitive streak is a structure that forms in the early embryo in amniotes. In amphibians, the equivalent structure is the blastopore. During early...
Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Signs and symptoms classically include abdominal pain...
connected to the uterus at the cervix. The uterus or womb accommodates the embryo, which develops into the fetus. The uterus also produces secretions, which...
Each fertilized ovum (zygote) may produce a single embryo, or it may split into two or more embryos, each carrying the same genetic material. Fetuses resulting...
mouth, and ears become visible. Also during this time, there is development of structures important to the support of the embryo, including the placenta...
primitive heart tube. The heart is the first functional organ in vertebrate embryos. The tubular heart quickly differentiates into the truncus arteriosus,...
eggs (nits) Nonviable eggs (dead embryo) that will never hatch Of these three, only eggs containing viable embryos have the potential to infest or reinfest...
the 19th century as model organisms in developmental biology, as their embryos were easy to observe. That has continued with studies of their genomes...
with the remaining aortic arches. Liver with the septum transversum. Human embryo 3 mm. long. Illustration of truncus arteriosus in a fully formed heart Failure...
first pharyngeal pouch and six small swellings that develop in the early embryo called otic placodes, which are derived from the ectoderm. The ear may be...
development, the stomach undergoes its first 90° rotation along the axis of the embryo, so that posterior structures are moved to the left and structures anterior...
medical terms as a spontaneous abortion, is the death and expulsion of an embryo or fetus before it can survive independently. The term miscarriage is sometimes...
among phyla; they generate the patterns in time and space which shape the embryo, and ultimately form the body plan of the organism. Another is that species...
They are formed very early during human development, and may be visible in embryos of as little as 55 mm in length (10 weeks of gestational age.) Shafik...
embryo development. This would facilitate comparisons between experiments in different laboratories. The devised their stage series based on visible anatomical...
from a wedding bus crash arrive. Among the victims is a woman with severe visible burns on whom Jared tries an experimental procedure and a young man with...
starts with vasculogenesis in the embryo. The human arterial and venous systems develop from different areas in the embryo. The arterial system develops mainly...
mesoparasitic copepod Pennella balaenopterae and its significance as a visible indicator of health status in dolphins (Delphinidae): a review" (PDF)....
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