This article is about a general overview of heart development. For protein signalling in heart development, see Protein signalling in heart development.
Heart development
Development of the human heart during the first five weeks (top), and the formation of the heart chambers (bottom) at four and eight weeks. In this figure, the blue and red colors represent blood inflow and outflow (not venous and arterial blood). Initially, all venous blood flows from the tail/atria to the ventricles/head, a very different pattern from that of an adult.[1][2]
Details
Gives rise to
Heart
System
Fetal circulation, circulatory system
Anatomical terminology
[edit on Wikidata]
Heart development, also known as cardiogenesis, refers to the prenatal development of the heart. This begins with the formation of two endocardial tubes which merge to form the tubular heart, also called the primitive heart tube. The heart is the first functional organ in vertebrate embryos.
The tubular heart quickly differentiates into the truncus arteriosus, bulbus cordis, primitive ventricle, primitive atrium, and the sinus venosus. The truncus arteriosus splits into the ascending aorta and the pulmonary trunk. The bulbus cordis forms part of the ventricles. The sinus venosus connects to the fetal circulation.
The heart tube elongates on the right side, looping and becoming the first visual sign of left-right asymmetry of the body. Septa form within the atria and ventricles to separate the left and right sides of the heart.[3]
^Cite error: The named reference CNX2014 was invoked but never defined (see the help page).
^Hosseini HS, Garcia KE, Taber LA (July 2017). "A new hypothesis for foregut and heart tube formation based on differential growth and actomyosin contraction". Development. 144 (13): 2381–2391. doi:10.1242/dev.145193. PMC 5536863. PMID 28526751.
^Anderson RH, Webb S, Brown NA, Lamers W, Moorman A (August 2003). "Development of the heart: (2) Septation of the atriums and ventricles". Heart. 89 (8): 949–958. doi:10.1136/heart.89.8.949. PMC 1767797. PMID 12860885.
Heartdevelopment, also known as cardiogenesis, refers to the prenatal development of the heart. This begins with the formation of two endocardial tubes...
of the Human Heart including vessels, internal and external features Prenatal human heartdevelopment Animal hearts: fish, squid The Heart, BBC Radio 4...
The heart is the first functional organ in a vertebrate embryo. There are 5 stages to heartdevelopment. Specification of cardiac precursor cells: The...
refer to a subset of cells in the development of the heart that play a vital role in the proper formation of the heart septa. They develop on the atrioventricular...
Embryogenesis Endoderm Eye development Gastrulation Germ layer Germ line development Gonadogenesis Heartdevelopment Histogenesis Limb development List of human cell...
The tubular heart or primitive heart tube is the earliest stage of heartdevelopment. From the inflow to the outflow, it consists of sinus venosus, primitive...
During heartdevelopment of a human embryo, the single primitive atrium becomes divided into right and left by a septum, the septum primum. The septum...
The septum secundum is a muscular flap that is important in heartdevelopment. It is semilunar in shape, and grows downward from the upper wall of the...
Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect in which the left side of the heart is severely underdeveloped and incapable...
ventricular septum, or during development septum inferius) is the stout wall separating the ventricles, the lower chambers of the heart, from one another. The...
may be the development of collateral circulation. Tetralogy of Fallot (ToF) Total anomalous pulmonary venous connection Hypoplastic left heart syndrome...
is highly expressed in the developing heart. Mutations of the JAG1 gene can lead to abnormal heartdevelopment associated with TOF. NKX2-5 codes for cardiac...
Developmental Biology. Sinauer Associates. Brand, Thomas (1 June 2003). "Heartdevelopment: molecular insights into cardiac specification and early morphogenesis"...
essential for early heartdevelopment, adult heart function and yolk sac vasculature remodeling and has been associated with congenital heart diseases. Tbx20...
fuses with the interventricular septum within the heart during heartdevelopment. In the developing heart, the truncus arteriosus and bulbus cordis are divided...
Atomic Heart is a first-person shooter video game developed by Russian game developer Mundfish and published by VK Play, Focus Entertainment, and 4Divinity...
into five key areas: research; heart and brain health; health equity; advocacy; and professional education and development. In 1924, six cardiologists Paul...
occurs during normal heartdevelopment, it also occurs in response to extensive exercise (athletic heart syndrome), heart disease, or heart muscle injury such...
trauma, infection and help lubricate the movement of the heart via pericardial fluid. The heart works by pumping blood around the body allowing oxygen,...
A broken heart (also known as heartbreak or heartache) is a metaphor for the intense emotional stress or pain one feels at experiencing great loss or...
Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood...
Sacred Heart of Jesus (Latin: Cor Jesu Sacratissimum) is one of the most widely practised and well-known Catholic devotions, wherein the heart of Jesus...
Heart Machine is an American independent video game development studio founded by Alx Preston. The studio is best known for developing Hyper Light Drifter...
hh homologues, SHH has been found to have the most critical roles in development, acting as a morphogen involved in patterning many systems—including...
Bradycardia, also called bradyarrhythmia, is a resting heart rate under 60 beats per minute (BPM). While bradycardia can result from various pathologic...
To Heart is a Japanese adult visual novel developed by Leaf and released on May 23, 1997 for Windows. It was later ported to the PlayStation and given...
Global Information