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For a modern description of the substance referred to as 'vagusstoff', see Acetylcholine.
Figure 1. Diagram of the frog heart preparation used by Loewi. Vagus nerve stimulation slows heart rate while accelerator (sympathetic) nerve stimulation speeds up heart rate.
Vagusstoff (literally translated from German as "Vagus Substance") refers to the substance released by stimulation of the vagus nerve which causes a reduction in the heart rate. Discovered in 1921 by physiologist Otto Loewi, vagusstoff was the first confirmation of chemical synaptic transmission and the first neurotransmitter ever discovered. It was later confirmed to be acetylcholine, which was first identified by Sir Henry Hallett Dale in 1914. Because of his pioneering experiments, in 1936 Loewi was awarded the Nobel Prize in Physiology or Medicine, which he shared with Dale.
Vagusstoff (literally translated from German as "Vagus Substance") refers to the substance released by stimulation of the vagus nerve which causes a reduction...
stimulation. Loewi described the substance released by the vagus nerve as vagusstoff, which was later found to be acetylcholine. Drugs that inhibit the muscarinic...
whilst working as a professor in the University of Graz. He named it vagusstoff ("vagus substance"), noted it to be a structural analog of choline and...
nerve was controlling the heart rate. He called the unknown chemical Vagusstoff, naming it after the nerve and the German word for substance. It was later...
Herznervenwirkung″ first in amphibians. He initially gave it the name Vagusstoff because it was released from the vagus nerve and in 1936 he wrote: ″I...
made using this technique include: The 1921 discovery by Otto Loewi of Vagusstoff using frog hearts resulted in the identification of acetylcholine as the...
the proximal synapses of the autonomic nervous system (initially named Vagusstoff by Loewi, and later identified as acetylcholine). The same happened to...
demonstrated the ″humorale Übertragbarkeit der Herznervenwirkung″ in amphibians. Vagusstoff transmitted inhibition from the vagus nerves, and Acceleransstoff transmitted...
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