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Organ bath information


Diagram of a typical organ bath preparation. An excised piece of smooth muscle tissue is held in an oxygenated solution in a chamber. The tissue is attached to a lever, which transmits its contraction to a myograph, thus recording the physiological response. Drugs under investigation can be administered directly to the chamber.

An organ chamber, organ bath, or isolated tissue bath, is a chamber in which isolated organs or tissues can be administered with drugs, or stimulated electrically, in order to measure their function. The tissue in the organ bath is typically oxygenated with carbogen and kept in a solution such as Tyrode's solution or lactated Ringer's solution.[citation needed] Historically, they have also been called gut baths.[1]

  1. ^ Handley, Sheila L.; Singh, Lakhbir (January 1986). "Neurotransmitters and shaking behaviour — more than a 'gut-bath' for the brain?". Trends in Pharmacological Sciences. 7: 324–328. doi:10.1016/0165-6147(86)90371-8.

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Organ bath

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An organ chamber, organ bath, or isolated tissue bath, is a chamber in which isolated organs or tissues can be administered with drugs, or stimulated...

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Bath Abbey

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Organ Register. British Institute of Organ Studies. 1971. Retrieved 18 September 2007.[permanent dead link] "Bath Abbey: The Smith of Bristol organ"...

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Respiratory system

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consists of gills, which are either partially or completely external organs, bathed in the watery environment. This water flows over the gills by a variety...

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Uterine contraction

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ex vivo. In these experiments, sections of myometrium are set up in an organ bath system that to measure changes in isometric force production. Following...

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Myograph

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used. In pharmacology, myography is used to record muscle contraction in organ bath preparations. The related technique of electromyography (EMG) is used...

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Pharmacology

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propelled pharmacological research and understanding. The development of the organ bath preparation, where tissue samples are connected to recording devices,...

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Volume of distribution

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observe that the drug has distributed out into some other volume (read organs/tissue). So probably the first question you want to ask is: how much of...

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Isolated organ perfusion technique

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can be similar to organ bath. Isolated organ perfusion technique, nevertheless, is averagely conducted in vivo without leaving the organ alone as a whole...

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Myofibroblast

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granulation tissue taken from a wound could contract in vitro (or in an organ bath) in a similar fashion to smooth muscle, when exposed to substances that...

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IC50

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relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)...

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Instruments used in pathology

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counting as in total blood count, differential count, etc. Tissue bath or organ bath or Dale's apparatus used in full tissue experiments, for example using...

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Diana Organ

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Diana Mary Organ (née Pugh; born 21 February 1952) is a British Labour Party politician who served as Member of Parliament (MP) for Forest of Dean from...

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Reverse pharmacology

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relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)...

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Classical pharmacology

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relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)...

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Ligand binding assay

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relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)...

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List of organists and assistant organists of Bath Abbey

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but nothing is known of this instrument. The first properly recorded organ in Bath Abbey was built by Abraham Jordan in 1708. It was modified in 1718 and...

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Eminent College of Pharmaceutical Technology

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Projection Microscope, Histamine Chamber, Actophotometer, Student's Organ Bath, Laminar Air Flow etc. are few instruments available in ECPT laboratories...

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Klais Orgelbau

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Germany. Bath Abbey in Bath, Somerset, UK. Beuron Archabbey church, Germany Basilica of Our Lady del Pilar in Saragossa, Spain, with 5.391 organ pipes inserted...

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George Joseph Smith

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Anthony Burgess's 1968 short story "An American Organ" wishes to emulate Smith by murdering his wife in a bath. Smith is mentioned and features at Madame Tussauds...

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Pharmacoepigenetics

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relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)...

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Voice of God

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(Deuteronomy 4:12). In this account, God reveals himself to man through the organs of hearing, not through those of sight. Even the prophet Ezekiel, who saw...

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Offal

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organ meats, is the internal organs of a butchered animal. The word does not refer to a particular list of edible organs, and these lists of organs vary...

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