The human gene VKORC1 encodes for the enzyme, Vitamin K epOxide Reductase Complex (VKORC) subunit 1.[5] This enzymatic protein complex is responsible for reducing vitamin K 2,3-epoxide to its active form, which is important for effective clotting (coagulation). In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors.
^ abcGRCh38: Ensembl release 89: ENSG00000167397 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000096145 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: VKORC1 vitamin K epoxide reductase complex, subunit 1".
The human gene VKORC1 encodes for the enzyme, Vitamin K epOxide Reductase Complex (VKORC) subunit 1. This enzymatic protein complex is responsible for...
last for up to five days. Because the mechanism involves enzymes such as VKORC1, patients on warfarin with polymorphisms of the enzymes may require adjustments...
Alberca I, Hermida J (April 2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated...
bacterial homolog, its own fused domain). The human gene for VKOR is called VKORC1 (VKOR complex subunit 1). It is the target of anticoagulant warfarin. Its...
it occurs in far smaller quantities in other plant tissues. Detection of VKORC1 homologues active on the K1-epioxide suggest that K1 may have a non-redox...
can change the metabolization speed of phenprocoumon. Polymorphisms of VKORC1, the gene coding for subunit 1 of vitamin K epoxide reductase, can influence...
drugs. However, with the discovery of polymorphic variants in CYP2C9 and VKORC1 genotypes, two genes that encode the individual anticoagulant response,...
it should. One gene that has been identified in warfarin resistance is VKORC1, a gene responsible for warfarin metabolism. It is inherited in an autosomal...
Wadelius M, Deloukas P (March 2009). "A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose"...
involving a germline mutation to a drug target is warfarin (Coumadin) and VKORC1, which codes for vitamin K epoxide reductase (VKOR). Warfarin binds to and...
and osteoporosis depending on the genetic variations in the CYP2C9, and VKORC1 gene. Since the prescription dose for warfarin varies by approximately 10-fold...
(June 2021). "A network meta-analysis of CYP2C9, CYP2C9 with VKORC1 and CYP2C9 with VKORC1 and CYP4F2 genotype-based warfarin dosing strategies compared...
Kenneth E.; Veenstra, David L.; Rettie, Allan E. (June 2, 2005). "Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose". The New England...
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