positive regulation by host of viral genome replication
endoplasmic reticulum unfolded protein response
endoplasmic reticulum to Golgi vesicle-mediated transport
response to unfolded protein
suppression of viral release by host
negative regulation by host of viral genome replication
positive regulation of viral genome replication
negative regulation by virus of viral protein levels in host cell
viral process
modulation by host of viral RNA genome replication
IRE1-mediated unfolded protein response
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9217
56491
Ensembl
ENSG00000124164
ENSMUSG00000054455
UniProt
O95292
Q9QY76 Q8BH80
RefSeq (mRNA)
NM_001195677 NM_004738
NM_019806
RefSeq (protein)
NP_001182606 NP_004729
NP_062780
Location (UCSC)
Chr 20: 58.39 – 58.45 Mb
Chr 2: 173.58 – 173.63 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene.[5][6] The VAPB gene is found on the 20th human chromosome. Together with VAPA, it forms the VAP protein family.
^ abcGRCh38: Ensembl release 89: ENSG00000124164 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000054455 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nishimura Y, Hayashi M, Inada H, Tanaka T (Jan 1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochemical and Biophysical Research Communications. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
^"Entrez Gene: VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C".
protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene. The VAPB gene is found on the 20th human chromosome. Together with VAPA, it...
unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations". PLOS ONE. 7 (6): e39261...
for vesicle-associated membrane protein. Humans have two VAPs: VAPA and VAPB This disambiguation page lists articles associated with the title VAP. If...
consist of two genes: VapC encodes a toxic PilT N-terminus (PIN) domain, and VapB encodes a matching antitoxin. The toxins in this family are thought to perform...
porcine PAI contains five full-length vap genes, including the vapA homologue, vapB. In addition to these unique genes, the PAI contains genes that have a known...
with VAPA and VAPB. Unlike FFAT and phospho-FFAT motifs, FFNT motifs primarily interact with MOSPD1 and MOSPD3, two homologs of VAPA, VAPB and MOSPD2. Two...
domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family...
A) is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum...
substantial number of familial ALS cases. Mutations in other genes (such as VAPB [2], ANG, TARDBP and FUS) have been reported, but are found at a much lower...
domain and linker plus transmembrane helix to attach to the ER: VAPA and VAPB. A third VAP-like protein is Motile sperm domain containing 2 (MOSPD2), which...
encoding enzyme Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog VAPB: VAMP (vesicle-associated membrane protein)-associated protein B and C YTHDF1:...
with the ER proteins VAPA and VAPB. Mutation of the phenylalanine residues in this motif or knockout of the VAPA and VAPB proteins results in a loss of...
AKAP11 has been shown to interact with: GSK3B, PPP1CA, PRKAR2A, PRKAR2B. VAPB. Binding is via a FFAT motif in the N-terminal portion of AKAP11, similar...
GPR37, SEC23IP, REEP2, and YIPF5. Studies suggest that interaction between VAPB and YIF1A control membrane delivery into dendrites. It also participates...
also encode predicted proteins with toxin-antitoxin (TA) domains, such as VapB, VapC, and xenobiotic response element. These proteins may play roles in...
Teuling E, Akhmanova A, Jaarsma D, Hoogenraad CC (2013). "The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane...