Phenotypic trait whose inheritance depends on multiple genes, with one having dominant influence
Oligogenic inheritance (Greek ὀλίγος – ὀligos = few, a little) describes a trait that is influenced by a few genes. Oligogenic inheritance represents an intermediate between monogenic inheritance in which a trait is determined by a single causative gene, and polygenic inheritance, in which a trait is influenced by many genes and often environmental factors.[1]
Historically, many traits were thought to be governed by a single causative gene (in what is deemed monogenic inheritance), however work in genetics revealed that these traits are comparatively rare, and in most cases so-called monogenic traits are predominantly influenced by one gene, but can be mediated by other genes of small effect.[2]
^Badano, Jose L.; Katsanis, Nicholas (October 2002). "Beyond Mendel: an evolving view of human genetic disease transmission". Nature Reviews Genetics. 3 (10): 779–789. doi:10.1038/nrg910. PMID 12360236. S2CID 4714288.
^Robinson, Jon F.; Katsanis, Nicholas (2010). "Oligogenic Disease". Vogel and Motulsky's Human Genetics. Springer, Berlin, Heidelberg. pp. 243–262. doi:10.1007/978-3-540-37654-5_8. ISBN 978-3-540-37653-8.
and 19 Related for: Oligogenic inheritance information
Oligogenicinheritance (Greek ὀλίγος – ὀligos = few, a little) describes a trait that is influenced by a few genes. Oligogenicinheritance represents an...
Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical...
et al. (November 2004). "A mixed epigenetic/genetic model for oligogenicinheritance of autism with a limited role for UBE3A". American Journal of Medical...
these loci. Characterization of human disease modifier genes and oligogenicinheritance holds promise for understanding the abundance of phenotypic variation...
kidney disease, since in this cases hypomorphic alleles and/or oligogenicinheritance can be involved; and 4- in patients requesting genetic counseling...
et al. (November 2004). "A mixed epigenetic/genetic model for oligogenicinheritance of autism with a limited role for UBE3A". American Journal of Medical...
characters, as opposed to the qualitative characters with monogenic or oligogenic determinism. In essence instead of two options, such as freckles or no...
syndrome: Identification of a novel KIF7 mutation and evidence for oligogenicinheritance". European Journal of Medical Genetics. 56 (1): 39–42. doi:10.1016/j...
been linked to AIP. This suggests that AIP inheritance instead follows an oligogenic or polygenic inheritance pattern. Research shows that HMBS mutations...
biological inheritance consists of three main categories: 1. Number of involved loci Monogenetic (also called "simple") – one locus Oligogenic – few loci...
contrast to a modifier gene. Major gene characterizes common expression of oligogenic series, i.e. a small number of genes that determine the same trait. Major...
Therefore, the condition is now thought to be oligogenic, with Locus heterogeneity and multiple forms of inheritance, and expression, implying that synesthesia...
10–15% of cases overall and can include monogenic, oligogenic, and polygenic modes of inheritance. There is considerable variation among clinicians on...
needed] Synesthesia might also be an oligogenic condition, with locus heterogeneity, multiple forms of inheritance, and continuous variation in gene expression...
a 2–5% concordance in shared inheritance. Since SLE is associated with many genetic regions, it is likely an oligogenic trait, meaning that there are...
individual with ALS have a 1% risk of developing ALS. ALS has an oligogenic mode of inheritance, meaning that mutations in two or more genes are required to...
Monasky MM, Micaglio E, Ciconte G, Pappone C (2020). "Brugada Syndrome: Oligogenic or Mendelian Disease?". Int J Mol Sci. 21 (5): 1687. doi:10.3390/ijms21051687...
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