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Triethylenetetramine information


Triethylenetetramine
Skeletal formula of triethylenetetramine
Ball and stick model of triethylenetetramine
Spacefill model of triethylenetetramine
Names
Preferred IUPAC name
N1,N1′-(Ethane-1,2-diyl)di(ethane-1,2-diamine)
Other names
  • N,N'-Bis(2-aminoethyl)ethane-1,2-diamine
  • TETA
  • trien
  • trientine (INN)
  • trientine dihydrochloride
  • MK-0681
Identifiers
CAS Number
  • 112-24-3 checkY
  • hydrochloride: 38260-01-4
3D model (JSmol)
  • Interactive image
Beilstein Reference
605448
ChEBI
  • CHEBI:39501 checkY
  • hydrochloride: CHEBI:9706
ChEMBL
  • ChEMBL609 checkY
  • hydrochloride: ChEMBL3989777
ChemSpider
  • 21106175 checkY
  • hydrochloride: 64521
DrugBank
  • DB06824
ECHA InfoCard 100.003.591 Edit this at Wikidata
EC Number
  • 203-950-6
Gmelin Reference
27008
KEGG
  • D00736 checkY
  • hydrochloride: D11649
MeSH Trientine
PubChem CID
  • 5565
  • hydrochloride: 71433
RTECS number
  • YE6650000
UNII
  • SJ76Y07H5F checkY
  • hydrochloride: HC3NX54582
UN number 2259
CompTox Dashboard (EPA)
  • DTXSID9023702 Edit this at Wikidata
InChI
  • InChI=1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2 checkY
    Key: VILCJCGEZXAXTO-UHFFFAOYSA-N checkY
SMILES
  • NCCNCCNCCN
Properties
Chemical formula
C6H18N4
Molar mass 146.238 g·mol−1
Appearance Colorless liquid
Odor Fishy, ammoniacal
Density 982 mg mL−1
Melting point −34.6 °C; −30.4 °F; 238.5 K
Boiling point 266.6 °C; 511.8 °F; 539.7 K
Solubility in water
Miscible
log P 1.985
Vapor pressure <1 Pa (at 20 °C)
Refractive index (nD)
1.496
Thermochemistry
Heat capacity (C)
376 J K−1 mol−1 (at 60 °C)
Hazards
GHS labelling:
Pictograms
GHS05: Corrosive GHS07: Exclamation mark
Signal word
Danger
Hazard statements
H312, H314, H317, H412
Precautionary statements
P273, P280, P305+P351+P338, P310
Flash point 129 °C (264 °F; 402 K)
Lethal dose or concentration (LD, LC):
LD50 (median dose)
  • 550 mg kg−1 (dermal, rabbit)
  • 2.5 g kg−1 (oral, rat)
Pharmacology
Legal status
  • CA: ℞-only[1][2]
Related compounds
Related amines
  • Ethylenediamine
  • Diethylenetriamine
  • Cyclam
Related compounds
  • Ethylenediaminetetraacetic acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Triethylenetetramine (TETA and trien), also known as trientine (INN) when used medically, is an organic compound with the formula [CH2NHCH2CH2NH2]2. The pure freebase is a colorless oily liquid, but, like many amines, older samples assume a yellowish color due to impurities resulting from air-oxidation. It is soluble in polar solvents. The branched isomer tris(2-aminoethyl)amine and piperazine derivatives may also be present in commercial samples of TETA.[3] The hydrochloride salts are used medically as a treatment for copper toxicity.

  1. ^ "Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
  2. ^ "Regulatory Decision Summary for Waymade-Trientine". Health Canada. 20 April 2021. Retrieved 25 March 2024.
  3. ^ "Ethyleneamines" (PDF). Huntsman. 2007. Archived from the original (PDF) on 2019-03-06. Retrieved 2016-07-10.

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Triethylenetetramine

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Triethylenetetramine (TETA and trien), also known as trientine (INN) when used medically, is an organic compound with the formula [CH2NHCH2CH2NH2]2. The...

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Tetraethylenepentamine

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It is soluble in most polar solvents. Diethylenetriamine (DETA), triethylenetetramine (TETA), piperazine, and aminoethylpiperazine are also usually present...

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Diethylenetriamine

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consume the explosive fill of land mines in beach and surf zones. Triethylenetetramine NIOSH Pocket Guide to Chemical Hazards. "#0211". National Institute...

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Ethylenediamine

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be recovered by rectification [de]. Diethylenetriamine (DETA) and triethylenetetramine (TETA) are formed as by-products. Another industrial route to ethylenediamine...

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Tetramine

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for a chemical containing four amine groups. Some examples are: Triethylenetetramine ("trien") Hexamethylenetetramine (hexamine) Tetramethylenedisulfotetramine...

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Amine

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Multifunctional amines such as tetraethylenepentamine and triethylenetetramine are also widely used in this capacity. The reaction proceeds by the...

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Epoxide

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epoxy glues and structural materials. A typical amine-hardener is triethylenetetramine (TETA). Epoxides are alkylating agents, making many of them highly...

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Denticity

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Tetradentate ligands bind with four donor atoms, an example being triethylenetetramine (abbreviated trien). For different central metal geometries there...

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C6H18N4

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The molecular formula C6H18N4 may refer to: Triethylenetetramine, an organic compound with the formula [CH2NHCH2CH2NH2]2 Tris(2-aminoethyl)amine, the organic...

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Teva Pharmaceuticals

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Terbinafin Testosterone Tiagabine Topiramate Tramadol Trazodone Triethylenetetramine Tri-Sprintec Ursodiol Valsartan Verapamil Velivet Venlafaxine Warfarin...

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Stability constants of complexes

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Deferiprone Penicillamine triethylenetetramine, TETA Ethylenediaminetetraacetic acid, EDTA Diethylenetriaminepentaacetic acid, DTPA Valinomycin Tri-n-butyl...

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Bausch Health

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Aciclovir (Zovirax), a topical antiviral used against herpes viruses Triethylenetetramine (Syprine), used for treatment of patients with Wilson's disease Loteprednol...

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Teta

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Teta may refer to: TETA, abbreviation for Triethylenetetramine 15374 Teta, an asteroid Teta Lando, an Angolan musician Teta Hyral, a character in Final...

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Ligand

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analogue Tricyclohexylphosphine P(C6H11)3 or PCy3 neutral monodentate Triethylenetetramine (trien) C6H18N4 neutral tetradentate Trimethylphosphine P(CH3)3 neutral...

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Ethylenediaminetetraacetic acid

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compounds Related alkanoic acids Daminozide Octopine Related compounds Triethylenetetramine Tetraacetylethylenediamine PMDTA Bis-tris propane Except where otherwise...

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Tetramethylethylenediamine

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rabbit) 268 mg kg−1 (oral, rat) Related compounds Related amines Triethylenetetramine Related compounds Tetraacetylethylenediamine Ethylenediaminetetraacetic...

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Amine value

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Ethylenediamine. Amine value = 1870 Diethylenetriamine. Amine value = 1634 Triethylenetetramine. Amine value = 1537 Aminoethylpiperazine. Amine value = 1305 Isophorone...

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Pentaethylenehexamine

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Related compounds Related compounds Tetraethylenepentamine TEPA Triethylenetetramine TETA Except where otherwise noted, data are given for materials in...

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PMDTA

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data sheet (SDS) sigmaaldrich.com Related compounds Related amines triethylenetetramine tmeda diethylenetriamine triazacyclononane Except where otherwise...

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Nitrate nitrite

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V. An investigation of the crystallization behavior of [cis-β-Co(triethylenetetramine)(NO2)2]X (X = I, NO3) and the crystal structure of racemic...

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Tetradentate ligand

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dimethyl ether TG3 CH3(OCH2CH2)3OCH3 linear OOOO 0 178.23 neutral Na, K Triethylenetetramine TETA trien [CH2NHCH2CH2NH2]2 linear NNNN 146.24 Cu2+...

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List of UN numbers 2201 to 2300

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Cyclohexene UN 2257 4.3 Potassium UN 2258 8 1,2-Propylenediamine UN 2259 8 Triethylenetetramine UN 2260 3 Tripropylamine UN 2261 6.1 Xylenols UN 2262 8 Dimethylcarbamoyl...

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Aminolysis

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For aminolysis, PET reacts with DETA (diethylenetriamine) or TETA (triethylenetetramine) which is polyamine. The reaction involves 200 - 210 Celsius. From...

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Selenidogermanate

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103.03° [{Ni(tepa)}2(μ-Ge2Se6)] tetragonal I41/a a=26.001 c=9.708 triethylenetetramine [Ni(teta)2]2Ge4Se10·0.5H2O monoclinic P21/c a 21.202 b 13.345 c 20...

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List of compounds with carbon number 6

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1722-26-5 C6H18N3P3 hexamethylcyclotriphosphazene 6607-30-3 C6H18N4 triethylenetetramine 112-24-3 C6H18O3Si3 hexamethylcyclotrisiloxane 54-15-9 C6H18O3Si3...

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Selenidostannate

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=20.5731 β =100.870° teta = triethylenetetramine (ethylenediamine)-(triethylenetetramine)-nickel(ii) (triethylenetetramine)-(N-(2-hydroxyethyl)ethylen...

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Aminoethylpiperazine

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distillation. These include ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, other higher homologues and aminoethyl piperazine...

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Palladium dicyanide

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tetramine 2,3,2-tet, H2N(CH2)2NH(CH2)3NH(CH2)2NH2, is similar to triethylenetetramine (2,2,2-tet) but has an additional methylene group between the two...

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Phosphate phosphite

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C2/c a = 33.929, b = 13.045, c = 8.971, β = 104.37°, Z = 4 3846 triethylenetetramine [C6N4H22]0.5[Zn3(PO4)2(HPO3)] 2:1 zinc potassium phosphitephosphate...

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