Transamidation is a chemical reaction in which an amide reacts with an amine to generate a new amide:
RC(O)NR'2 + HNR"2 → RC(O)NR"2 + HNR'2
The reaction is typically very slow, but it can be accelerated with Lewis acid[1] and organometallic catalysts.[2] Primary amides (RC(O)NH2) are more amenable to this reaction.
^T. A. Dineen; M. A. Zajac; A. G. Myers (2006). "Efficient Transamidation of Primary Carboxamides by in situ Activation with N,N-Dialkylformamide Dimethyl Acetals". J. Am. Chem. Soc. 128 (50): 16406–16409. doi:10.1021/ja066728i. PMID 17165798.
^Emma L. Baker; Michael M. Yamano; Yujing Zhou; Sarah M. Anthony; Neil K. Garg (2016). "A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis". Nature Communications. 7: 11554. Bibcode:2016NatCo...711554B. doi:10.1038/ncomms11554. PMC 4876455. PMID 27199089.
Transamidation is a chemical reaction in which an amide reacts with an amine to generate a new amide: RC(O)NR'2 + HNR"2 → RC(O)NR"2 + HNR'2 The reaction...
S2CID 43671648. T. A. Dineen; M. A. Zajac; A. G. Myers (2006). "Efficient Transamidation of Primary Carboxamides by in situ Activation with N,N-Dialkylformamide...
body through excretion. Biurea is produced from urea and hydrazine by transamidation. Its major use is as a chemical intermediate in the production of azodicarbonamide...
the amino group is then fed into the urea cycle. The other product of transamidation is a keto acid that enters the citric acid cycle. Glucogenic amino acids...
of blends to be made. The two polymers can react with one another by transamidation to form random copolymers. According to their crystallinity, polyamides...
effectively. These peptides are modified by tTG in two ways, deamidation or transamidation. Deamidation is the reaction by which a glutamate residue is formed...
nucleus, and the plasma membrane. It requires calcium as a cofactor for transamidation activity. Transcription is increased by retinoic acid. Among its many...
transglutaminases have been characterised in humans, eight of which catalyse transamidation reactions. These TGases have a three or four-domain organization, with...
because it does not show strong antibiotic activity. The final step is a transamidation by isopenicillin N N-acyltransferase, in which the α-aminoadipyl side-chain...
type of covalent bonds termed isopeptide bonds, in a reaction termed transamidation or crosslinking. Transglutaminase binding of these proteins and peptides...
heterotrimeric enzyme that catalyses the formation of Gln-tRNA(Gln) by the transamidation of misacylated Glu-tRNA(Gln) via amidolysis of glutamine. As of late...
thioureas: HNR2 + S=C=NR' → S=C(NR2)(NHR') Cyclic thioureas are prepared by transamidation of thiourea with diamines. Ethylene thiourea is synthesized by treating...
transfer. The mechanism commonly ascribed to SHMT enzymatic activity is a transamidation followed by a cleavage of amino acid side chain from the backbone. The...
PMC 5293005. PMID 27317943. Muma NA, Mi Z (July 2015). "Serotonylation and Transamidation of Other Monoamines". ACS Chemical Neuroscience. 6 (7): 961–969. doi:10...
4049/jimmunol.175.12.8296. PMID 16339570. Cecil DL, Terkeltaub R (June 2008). "Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic...
beginning of a transreaction process (e. g. transesterification or transamidation), the degree of randomness χ ≈ 0 as the system comprises a physical...
mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs...
Global Information