3D structure of thiosulfate dehydrogenase with thiosulfate substrate present in the active site, corresponding to RCSB code 4V2K
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1.8.2.2
CAS no.
9076-88-4
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Thiosulfate dehydrogenase (abbreviated as TsdA) (EC 1.8.2.2) is an enzyme that catalyzes the chemical reaction:[1]
2 thiosulfate + 2 ferricytochrome c tetrathionate + 2 ferrocytochrome c
Thus, the two substrates of this enzyme are thiosulfate and ferricytochrome c, whereas its two products are tetrathionate and ferrocytochrome c.
Thiosulfate dehydrogenase homologues have been isolated from numerous bacterial species and differ slightly in structure but have analogous function and mechanism of sulfur oxidation. The enzyme is similar in both function and structure to a few enzymes in the Sox sulfur oxidation pathway.[2]
^Lu WP, Kelly DP (1988). "Cellular Location and Partial Purification of the 'Thiosulphate-oxidizing Enzyme' and 'Trithionate Hydrolyase' from Thiobacillus tepidarius". Microbiology. 134 (4): 877–885. doi:10.1099/00221287-134-4-877.
^Bamford, V. A. (2002). "Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme". The EMBO Journal. 21 (21): 5599–5610. doi:10.1093/emboj/cdf566. ISSN 1460-2075. PMC 131063. PMID 12411478.
and 19 Related for: Thiosulfate dehydrogenase information
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