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Tetrazole information


1H-Tetrazole
Identifiers
CAS Number
  • 288-94-8 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:33193 checkY
ChemSpider
  • 60842 checkY
ECHA InfoCard 100.005.477 Edit this at Wikidata
PubChem CID
  • 67519
UNII
  • D34J7PAT68 checkY
CompTox Dashboard (EPA)
  • DTXSID5075280 Edit this at Wikidata
InChI
  • InChI=1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5) checkY
    Key: KJUGUADJHNHALS-UHFFFAOYSA-N checkY
  • InChI=1/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)
    Key: KJUGUADJHNHALS-UHFFFAOYAI
  • InChI=1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)
    Key: KJUGUADJHNHALS-UHFFFAOYSA-N
SMILES
  • [nH]1nnnc1
Properties
Chemical formula
CH2N4
Molar mass 70.05 g/mol
Density 1.477 g/mL
Melting point 157 to 158 °C (315 to 316 °F; 430 to 431 K)[2]
Boiling point 220 ± 23 °C (428 ± 41 °F; 493 ± 23 K)
Acidity (pKa) 4.90[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Tetrazoles are a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen atoms and one carbon atom. The name tetrazole also refers to the parent compound with formula CH2N4, of which three isomers can be formulated.

  1. ^ Satchell, Jacqueline F.; Smith, Brian J. (2002). "Calculation of aqueous dissociation constants of 1,2,4-triazole and tetrazole: A comparison of solvation models". Phys. Chem. Chem. Phys. 4 (18): 4314–4318. Bibcode:2002PCCP....4.4314S. doi:10.1039/b203118c.
  2. ^ Mihina, Joseph S.; Herbst, Robert M. (1950). "The Reaction of Nitriles with Hydrazoic Acid: Synthesis of Monosubstituted Tetrazoles". J. Org. Chem. 15 (5): 1082–1092. doi:10.1021/jo01151a027.

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Tetrazole

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Tetrazoles are a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen atoms and one carbon atom. The name tetrazole...

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aromatized negatively charged tetrazole, called "losartan potassium". The molecule has an extended biphenyl group with a tetrazole which is being used in place...

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allows tetrazoles to be used wavelength selectively in combination with another photoligation reaction, where at the short wavelength the tetrazole ligation...

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or ARB medications. The medicine has an extended diphenyl group with a tetrazole at the 2-prime position. At the 4'prime position, the molecule has a diazaspiro04-none...

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nucleophiles catalyzed by weak acids e.c., triethylammonium chloride or 1H-tetrazole. In these reactions, the incoming nucleophile replaces the NR2 moiety...

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both alkenes and tetrazoles into biomolecules using simple biological methods such as genetic encoding. Additionally, the tetrazole can be designed to...

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Explosive

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Azidotetrazolates Azoclathrates Benzoyl peroxide Benzvalene 3,5-Bis(trinitromethyl)tetrazole Chlorine oxides Copper(I) acetylide Copper(II) azide Cumene hydroperoxide...

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Nitro blue tetrazolium is a chemical compound composed of two tetrazole moieties. It is used in immunology for sensitive detection of alkaline phosphatase...

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and closed forms of certain heterocycles, such as organic azides and tetrazoles, or mesoionic münchnone and acylamino ketene. Valence tautomerism requires...

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irbesartan, olmesartan, candesartan, valsartan, fimasartan include the tetrazole group (a ring with four nitrogen and one carbon). Losartan, irbesartan...

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ATC code J02

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ATC code J02 Antimycotics for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric...

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nitrogen atoms. This set contains pyrrole, imidazole, pyrazole, triazoles, tetrazole, and pentazole. Substituted analogs of pentazole are collectively known...

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in the dark since the MTT reagent is sensitive to light. MTT, a yellow tetrazole, is reduced to purple formazan in living cells. A solubilization solution...

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histidine. Nitrogen only Imidazole Pyrazole 1,2,3-Triazole 1,2,4-Triazole Tetrazole Pentazole N,O compounds Oxazole Isoxazole 1,2,3-oxadiazole (unstable)...

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Heterocyclic compound

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Furazan Oxadiazole N N S Thiadiazole N O O Dioxazole N S S Dithiazole N N N N Tetrazole N N N N O Oxatetrazole N N N N S Thiatetrazole N N N N N Pentazole...

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which have a tetrazole attached to the molecule, azilsartan has an oxadiazole, which has an acidic proton at the nitrogen. The tetrazole represents a...

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Oxidation state

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S2CID 206540959. Tetrazoles contain a pair of double-bonded nitrogen atoms with oxidation state 0 in the ring. A Synthesis of the parent 1H-tetrazole, CH2N4 (two...

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Takata Corporation

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to tetrazole) Sodium azide (old highly stable airbag propellant phased out by Takata in the 1990s in favor of the less potentially toxic tetrazole) Guanidine...

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Oligonucleotide synthesis

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4-dimethylaminopyridine (DMAP) and either tetrazole, 5-(o-nitrophenyl)tetrazole, or 5-(p-nitrophenyl)tetrazole in the solid phase synthesis of oligoribonucleotides...

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Nitrogen

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January 2019. Tetrazoles contain a pair of double-bonded nitrogen atoms with oxidation state 0 in the ring. A Synthesis of the parent 1H-tetrazole, CH2N4 (two...

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Azidotetrazolate

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series of salts. The ion is made by removing a proton from 5-azido-1H-tetrazole. The molecular structure contains a five-membered ring with four nitrogen...

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MTT

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MTT assay using dimethyl thiazolyl diphenyl tetrazolium salt, a type of tetrazole Multi-transaction translator, a particular functional unit in USB hubs...

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Triazole

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nonadjacent nitrogen atoms Pyrazole, an analog with two adjacent nitrogen atoms Tetrazole, an analog with four nitrogen atoms Triazolium salts, substituted analogues...

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Disulfiram

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including cefoperazone, cefamandole and cefotetan, that have a N-methylthio-tetrazole moiety Griseofulvin, an oral antifungal drug Procarbazine Temposil, or...

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