Teriflunomide, sold under the brand name Aubagio, is the active metabolite of leflunomide.[4] Teriflunomide was investigated in the Phase III clinical trial TEMSO as a medication for multiple sclerosis (MS). The study was completed in July 2010.[5] 2-year results were positive.[6] However, the subsequent TENERE head-to-head comparison trial reported that "although permanent discontinuations [of therapy] were substantially less common among MS patients who received teriflunomide compared with interferon beta-1a, relapses were more common with teriflunomide."[7] The drug was approved for use in the United States in September 2012[8][9] and for use in the European Union in August 2013.[10]
^ ab"Teriflunomide (Aubagio) Use During Pregnancy". Drugs.com. 11 September 2019. Retrieved 2 March 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^Magne D, Mézin F, Palmer G, Guerne PA (November 2006). "The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha". Inflammation Research. 55 (11): 469–75. doi:10.1007/s00011-006-5196-x. PMID 17122964. S2CID 47034503.
^Clinical trial number NCT00134563 for "Phase III Study of Teriflunomide in Reducing the Frequency of Relapses and Accumulation of Disability in Patients With Multiple Sclerosis (TEMSO)" at ClinicalTrials.gov
^"Sanofi-Aventis' Teriflunomide Comes Up Trumps in Two-Year Phase III MS Trial". Genetic Engineering & Biotechnology News. 15 October 2010.
^Gever J (4 June 2012). "Teriflunomide Modest Help but Safe for MS". medpage. Joint meeting of the Consortium of Multiple Sclerosis Centers and the Americas Committee for Treatment and Research in Multiple Sclerosis. Retrieved 4 June 2012.
^"Drug Approval Package: Aubagio (teriflunomide) Tablets NDA #202992". U.S. Food and Drug Administration (FDA). 5 November 2012. Retrieved 1 March 2020.
^"FDA approves new multiple sclerosis treatment Aubagio" (Press release). U.S. Food and Drug Administration (FDA). Archived from the original on 13 September 2012. Retrieved 14 September 2012.
^"Aubagio EPAR". European Medicines Agency (EMA). 26 February 2020. Retrieved 1 March 2020.
Teriflunomide, sold under the brand name Aubagio, is the active metabolite of leflunomide. Teriflunomide was investigated in the Phase III clinical trial...
opened and teriflunomide is formed. "Regardless of the substance administered (leflunomide or teriflunomide), it is the same molecule (teriflunomide)—the one...
to that of adults. The role of some newer agents such as fingolimod, teriflunomide, and dimethyl fumarate, is not yet entirely clear. Making firm conclusions...
leflunomide or teriflunomide to aid drug elimination in the case of drug discontinuation due to severe side effects caused by leflunomide or teriflunomide. A case...
weeks. Participants were randomized to receive either ublituximab or teriflunomide, the active comparator. The primary outcome of both studies was the...
given in parentheses following the brand name. – Autoimmune Aubagio (Teriflunomide), small molecule for multiple sclerosis. Approved by the FDA in September...
under the Revox tradename Other Sony Alpha 77, camera made by Sony Teriflunomide (A77 1726), the active metabolite of leflunomide Benoni Defense in the...
as well as in multiple sclerosis. Examples include Leflunomide and Teriflunomide (the active metabolite of leflunomide). In order to understand how life...
Comi G, Correale J, Coyle PK, et al. (August 2020). "Ofatumumab versus Teriflunomide in Multiple Sclerosis". The New England Journal of Medicine. 383 (6):...
sclerosis drugs, some of which can be taken orally (Dimethyl fumarate, teriflunomide, others). Yasmin / Yaz birth control pills are part of a group of birth...
including influenza, Zika virus, Ebola virus and SARS-CoV-2. Brequinar Teriflunomide Leflunomide Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, et al. (October...
new inflammatory lesions on brain MRI by 56% compared to those taking teriflunomide. In October 2020, Janseen-Cilag International NV submitted an application...
C12H9F3N2O2 (molar mass: 270.21 g/mol, exact mass: 270.0616 u) may refer to: Teriflunomide Leflunomide This set index page lists chemical structure articles associated...
Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups. Ofatumumab versus Teriflunomide in Multiple Sclerosis. N Engl J Med 6;383(6):546-557. Klotz L*, Eschborn...
pembrolizumab for small-cell lung cancer; fingolimod, dimethyl fumarate, teriflunomide, alemtuzumab, and daclizumab for multiple sclerosis; and ixekizumab...
Global Information
(what is this?) (verify)