TRPC3 information

TRPC3
Identifiers
Aliases	TRPC3, SCA41, TRP3, transient receptor potential cation channel subfamily C member 3
External IDs	OMIM: 602345; MGI: 109526; HomoloGene: 20708; GeneCards: TRPC3; OMA:TRPC3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	121,952,060 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	36,744,316 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; secondary oocyte; ; endothelial cell; ; pituitary gland; ; testicle; ; anterior pituitary; ; ventricular zone; ; gastric mucosa; ; gonad; ; putamen;
	Top expressed in
	lobe of cerebellum; ; lumbar spinal ganglion; ; cerebellar vermis; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; lateral septal nucleus; ; medial vestibular nucleus; ; nucleus of stria terminalis; ; superior colliculus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	store-operated calcium channel activity; calcium channel activity; inositol 1,4,5 trisphosphate binding; ion channel activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cation channel complex;
Biological process	response to ATP; positive regulation of calcium ion transport into cytosol; ion transport; single fertilization; platelet activation; response to calcium ion; calcium ion transmembrane transport; positive regulation of cardiac muscle hypertrophy in response to stress; manganese ion transport; calcium ion transport; phototransduction; transmembrane transport; regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	7222
	22065
	ENSG00000138741
	ENSMUSG00000027716
	Q13507
	Q9QZC1
	NM_001130698; NM_003305; NM_001366479
	NM_019510
	NP_001124170; NP_003296; NP_001353408
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell growth, proliferation and pathological hypertrophy.^[5] These are diacylglycerol-sensitive cation channels known to regulate intracellular calcium via activation of the phospholipase C (PLC) pathway and/or by sensing Ca2+ store depletion.^[6] Together, their role in calcium homeostasis has made them potential therapeutic targets for a variety of central and peripheral pathologies.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138741 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027716 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg CG (2013-01-29). "Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists". Biophysical Journal. 104 (2, Supplement 1): 454a. Bibcode:2013BpJ...104..454X. doi:10.1016/j.bpj.2012.11.2513.
^ Fusco FR, Martorana A, Giampà C, De March Z, Vacca F, Tozzi A, Longone P, Piccirilli S, Paolucci S, Sancesario G, Mercuri NB, Bernardi G (July 2004). "Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes". Neuroscience Letters. 365 (2): 137–42. doi:10.1016/j.neulet.2004.04.070. PMID 15245795. S2CID 27636840.
^ Kaneko Y, Szallasi A (2013-01-01). "TRP channels as therapeutic targets". Current Topics in Medicinal Chemistry. 13 (3): 241–3. doi:10.2174/1568026611313030001. PMID 23432057.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138741 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027716 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Xu_2013-5] Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg CG (2013-01-29). "Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists". Biophysical Journal. 104 (2, Supplement 1): 454a. Bibcode:2013BpJ...104..454X. doi:10.1016/j.bpj.2012.11.2513.

[Fusco_FR_2004-6] Fusco FR, Martorana A, Giampà C, De March Z, Vacca F, Tozzi A, Longone P, Piccirilli S, Paolucci S, Sancesario G, Mercuri NB, Bernardi G (July 2004). "Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes". Neuroscience Letters. 365 (2): 137–42. doi:10.1016/j.neulet.2004.04.070. PMID 15245795. S2CID 27636840.

[7] Kaneko Y, Szallasi A (2013-01-01). "TRP channels as therapeutic targets". Current Topics in Medicinal Chemistry. 13 (3): 241–3. doi:10.2174/1568026611313030001. PMID 23432057.

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