TLE3 information

TLE3
Identifiers
Aliases	TLE3, ESG, ESG3, GRG3, HsT18976, transducin like enhancer of split 3, TLE family member 3, transcriptional corepressor
External IDs	OMIM: 600190 MGI: 104634 HomoloGene: 21059 GeneCards: TLE3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	70,098,176 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	61,325,779 bp
RNA expression pattern
	Top expressed in
	blood; ; ganglionic eminence; ; sural nerve; ; monocyte; ; skin of abdomen; ; vagina; ; spleen; ; canal of the cervix; ; right lung; ; minor salivary glands;
	Top expressed in
	hair follicle; ; lacrimal gland; ; intestinal villus; ; molar; ; blood; ; lip; ; maxillary prominence; ; ileum; ; thymus; ; pineal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription corepressor activity;
Cellular component	nucleus; nucleoplasm; beta-catenin-TCF complex; transcription regulator complex;
Biological process	animal organ morphogenesis; regulation of transcription, DNA-templated; Wnt signaling pathway; transcription, DNA-templated; signal transduction; beta-catenin-TCF complex assembly; negative regulation of canonical Wnt signaling pathway; negative regulation of cold-induced thermogenesis; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	7090
	21887
	ENSG00000140332
	ENSMUSG00000032280
	Q04726; Q6PRX3
	Q08122
NM_001105192; NM_001282979; NM_001282980; NM_001282981; NM_001282982;
	NM_005078; NM_020908
	NM_001083927; NM_001083928; NM_009389
NP_001098662; NP_001269908; NP_001269909; NP_001269910; NP_001269911;
	NP_005069; NP_065959; NP_001269908.1
	NP_001077396; NP_001077397; NP_033415
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140332 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032280 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
^ "Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140332 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032280 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8365415-5] Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.

[entrez-6] "Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)".

TLE3 information

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WD40 repeat

TBX15

HESX1