TLE2 information

TLE2
Identifiers
Aliases	TLE2, ESG, ESG2, GRG2, transducin like enhancer of split 2, TLE family member 2, transcriptional corepressor
External IDs	OMIM: 601041 MGI: 104635 HomoloGene: 20693 GeneCards: TLE2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,047,635 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,426,679 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; cerebellar vermis; ; tibial nerve; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left uterine tube; ; parotid gland; ; sural nerve; ; minor salivary glands; ; canal of the cervix;
	Top expressed in
	cerebellar cortex; ; medullary collecting duct; ; cerebellar vermis; ; internal carotid artery; ; adrenal gland; ; superior frontal gyrus; ; molar; ; external carotid artery; ; saccule; ; ovary;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription corepressor activity;
Cellular component	nucleus; focal adhesion; nucleoplasm; extracellular space; nuclear body; transcription regulator complex;
Biological process	animal organ morphogenesis; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; transcription, DNA-templated; signal transduction; beta-catenin-TCF complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7089
	21886
	ENSG00000065717
	ENSMUSG00000034771
	Q04725
	Q9WVB2
	NM_001144761; NM_001144762; NM_001300846; NM_003260
	NM_001252401; NM_019725
	NP_001138233; NP_001138234; NP_001287775; NP_003251
	NP_001239330; NP_062699
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065717 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034771 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Oct 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
^ "Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065717 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034771 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8808280-5] Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Oct 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.

[entrez-6] "Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)".

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