TIRAP information

TIRAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y92, 3UB2, 3UB3, 3UB4, 4FZ5, 4LQD
Identifiers
Aliases	TIRAP, BACTS1, Mal, MyD88-2, wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TIR domain containing adaptor protein
External IDs	OMIM: 606252; MGI: 2152213; HomoloGene: 14285; GeneCards: TIRAP; OMA:TIRAP - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	126,298,845 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	35,111,587 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; monocyte; ; bone marrow cells; ; islet of Langerhans; ; rectum; ; smooth muscle tissue; ; left ovary; ; right ovary; ; right lobe of liver; ; minor salivary glands;
	Top expressed in
	triceps brachii muscle; ; vastus lateralis muscle; ; conjunctival fornix; ; sternocleidomastoid muscle; ; primitive streak; ; temporal muscle; ; knee joint; ; parotid gland; ; cumulus cell; ; otic placode;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein homodimerization activity; Toll-like receptor 2 binding; Toll-like receptor 4 binding; protein binding; protein heterodimerization activity; phosphatidylinositol-4,5-bisphosphate binding; protein kinase C binding; identical protein binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; endocytic vesicle; ruffle membrane;
Biological process	myeloid cell differentiation; regulation of innate immune response; cellular response to bacterial lipopeptide; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of interleukin-12 production; positive regulation of chemokine (C-X-C motif) ligand 1 production; positive regulation of chemokine (C-X-C motif) ligand 2 production; immune system process; positive regulation of JNK cascade; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-15 production; positive regulation of protein homodimerization activity; cell surface receptor signaling pathway; response to lipopolysaccharide; TIRAP-dependent toll-like receptor 4 signaling pathway; cellular response to lipoteichoic acid; positive regulation of B cell proliferation; regulation of interferon-beta production; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-8 production; positive regulation of ERK1 and ERK2 cascade; positive regulation of neutrophil chemotaxis; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of toll-like receptor 2 signaling pathway; 3'-UTR-mediated mRNA stabilization; inflammatory response; signal transduction; defense response to Gram-positive bacterium; innate immune response; activation of NF-kappaB-inducing kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	114609
	117149
	ENSG00000150455
	ENSMUSG00000032041
	P58753
	Q99JY1
	NM_001039661; NM_052887; NM_148910; NM_001318776; NM_001318777
	NM_001177845; NM_001177846; NM_001177847; NM_054096
	NP_001034750; NP_001305705; NP_001305706; NP_683708
	NP_001171316; NP_001171317; NP_001171318; NP_473437
	Wikidata
View/Edit Human	View/Edit Mouse

TIRAP (TIR domain containing adaptor protein) is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150455 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032041 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150455 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032041 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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