TAS2R46 information

TAS2R46
Identifiers
Aliases	TAS2R46, T2R46, T2R54, taste 2 receptor member 46
External IDs	OMIM: 612774; MGI: 2681256; HomoloGene: 135705; GeneCards: TAS2R46; OMA:TAS2R46 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,062,294 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	132,634,807 bp
RNA expression pattern
	Top expressed in
	testicle; ; corpus callosum; ; Achilles tendon; ; tonsil; ; epithelium of colon; ; muscle of thigh; ; skeletal muscle tissue; ; cell; ; stromal cell of endometrium; ; ventricular zone;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; bitter taste receptor activity;
Cellular component	plasma membrane; cell projection; cilium; membrane; ciliary membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	259292
	387348
	ENSG00000278111; ENSG00000262525; ENSG00000226761
	ENSMUSG00000059382
	P59540
	Q7M721
	NM_176887
	NM_207023
	NP_795368
	NP_996906
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptors for bitter substances (T2Rs/TAS2Rs) belong to the family of G-protein coupled receptors and are related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception.^[5]

Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.^[6]^[7]

^ ^a ^b ^c ENSG00000262525, ENSG00000226761 GRCh38: Ensembl release 89: ENSG00000278111, ENSG00000262525, ENSG00000226761 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059382 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. (February 2010). "The molecular receptive ranges of human TAS2R bitter taste receptors". Chemical Senses. 35 (2): 157–170. doi:10.1093/chemse/bjp092. PMID 20022913.
^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (November 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nature Genetics. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.
^ "Entrez Gene: TAS2R46 taste receptor, type 2, member 46".

[refGRCh38Ensembl-1] ENSG00000262525, ENSG00000226761 GRCh38: Ensembl release 89: ENSG00000278111, ENSG00000262525, ENSG00000226761 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059382 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. (February 2010). "The molecular receptive ranges of human TAS2R bitter taste receptors". Chemical Senses. 35 (2): 157–170. doi:10.1093/chemse/bjp092. PMID 20022913.

[pmid12379855-6] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (November 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nature Genetics. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.

[entrez-7] "Entrez Gene: TAS2R46 taste receptor, type 2, member 46".

TAS2R46 information

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TAS2R46

Denatonium

Strychnine

Taste receptor