Micrograph of a monophasic synovial sarcoma. The histologic appearance is non-specific and overlaps with MPNST and fibrosarcoma. H&E stain.
Specialty
Oncology
A synovial sarcoma (also known as malignant synovioma[1]) is a rare form of cancer which occurs primarily in the extremities of the arms or legs, often in proximity to joint capsules and tendon sheaths.[2] It is a type of soft-tissue sarcoma.
The name "synovial sarcoma" was coined early in the 20th century, as some researchers thought that the microscopic similarity of some tumors to synovium, and its propensity to arise adjacent to joints, indicated a synovial origin; however, the actual cells from which the tumor develops are unknown and not necessarily synovial.[3]
Primary synovial sarcomas are most common in the soft tissue near the large joints of the arm and leg but have been documented in most human tissues and organs, including the brain, prostate, and heart.
Synovial sarcoma occurs in about 1–2 per 1,000,000 people a year.[4] They occur most commonly in the third decade of life, with males being affected more often than females (ratio around 1.2:1).[4][2]
^"Synovioma". Encyclopædia Britannica Online. Retrieved 20 May 2012.
^ abGoldblum, John R.; Folpe, Andrew L.; Weiss, Sharon W. (2001). "33". Enzinger and Weiss's Soft Tissue Tumors (Sixth ed.). St Louis, Missouri: CV Mosby. pp. 1052–1070. ISBN 978-0323088343. LCCN 2013010770.
^Pollock, Raphael E., ed. (2002). Soft Tissue Sarcomas. American Cancer Society Atlas of Clinical Oncology. BC Decker. ISBN 155009128X.
^ abFerrari and Collini (2012). "Synovial Sarcoma". ESUN. 9 (5).
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Epithelioid sarcoma is a rare soft tissue sarcoma arising from mesenchymal tissue and characterized by epithelioid-like features. It accounts for less...
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The product of this gene belongs to the family of highly homologous synovialsarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional...
Translocations have also been described in solid malignancies such as Ewing's sarcoma. Infertility: One of the would-be parents carries a balanced translocation...
SS18 is involved in a chromosomal translocation commonly found in synovialsarcoma. SS18 has been shown to interact with: EP300, MLLT10, SMARCA2, and...
Merrick, New York, on May 14, 1985. While in high school, he overcame synovialsarcoma, which had started in his foot and spread to his lungs. He was forced...
The product of this gene belongs to the family of highly homologous synovialsarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional...
"Regenerative Medicine Advanced Therapy Designation Granted to ADP-A2M4 for SynovialSarcoma". Journal of Oncology Navigation & Survivorship. 2019-12-11. "FDA Grants...
Shaanxi who died after receiving DC-CIK, an experimental treatment for synovialsarcoma at the Second Hospital of the Beijing Armed Police Corps, which he...
after both Finnegan's sister and a girl he met while she was battling synovialsarcoma. "2006 NFL Draft Listing". Pro-Football-Reference.com. Retrieved May...
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