Global InformationSunflower trypsin inhibitor information
Sunflower trypsin inhibitor (SFTI) is a small, circular peptide produced in sunflower seeds, and is a potent inhibitor of trypsin. It is the smallest known member of the Bowman-Birk family of serine protease inhibitors.[1]
One example of Sunflower trypsin inhibitor is Sunflower trypsin inhibitor-1 (SFTI-1). Sunflower trypsin inhibitor-1 is a potent Bowman-Birk inhibitor. Sunflower trypsin inhibitor-1 is the simplest cysteine-rich peptide scaffold because it is a bicyclic 14 amino acid peptide and only has one disulfide bond. The disulfide bond divides the peptide into two loops. One loop is a functional trypsin inhibitory and the second loop is a nonfunctional loop.[2] The nonfunctional loop can be replaced by a bioactive loop. It is extracted from a seed of a sunflower called Helianthus annuus. The synthesis of SFTI is not known however, it can evolutionarily linked to a gene-coded product from classic Bowman-Birk inhibitors.[3] STFI is used in radiopharmaceutical, antimicrobial, and pro-angiogenic peptides.[2]
- ^ Luckett S, Garcia RS, Barker JJ, Konarev AV, Shewry PR, Clarke AR, Brady RL (July 1999). "High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds". Journal of Molecular Biology. 290 (2): 525–33. doi:10.1006/jmbi.1999.2891. PMID 10390350.
- ^ a b Qiu Y, Taichi M, Wei N, Yang H, Luo KQ, Tam JP (January 2017). "1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor". Journal of Medicinal Chemistry. 60 (1): 504–510. doi:10.1021/acs.jmedchem.6b01011. PMID 27977181.
- ^ Korsinczky ML, Schirra HJ, Craik DJ (October 2004). "Sunflower trypsin inhibitor-1". Current Protein & Peptide Science. 5 (5): 351–64. doi:10.2174/1389203043379594. PMID 15544530.