General chemical structure of substituted benzofurans
The substituted benzofurans are a class of chemical compounds based on the heterocyclyc and polycyclic compound benzofuran. Many medicines use the benzofuran core as a scaffold,[1][2][3] but most commonly the term is used to refer to the simpler compounds in this class which include numerous psychoactive drugs, including stimulants, psychedelics and empathogens. In general, these compounds have a benzofuran core to which a 2-aminoethyl group is attached (at any position), and combined with a range of other substituents.[4][5][6][7] Some psychoactive derivatives from this family have been sold under the name Benzofury.[8]
^Dawood KM (September 2013). "Benzofuran derivatives: a patent review". Expert Opinion on Therapeutic Patents. 23 (9): 1133–56. doi:10.1517/13543776.2013.801455. PMID 23683135. S2CID 24425145.
^Nevagi RJ, Dighe SN, Dighe SN (June 2015). "Biological and medicinal significance of benzofuran". European Journal of Medicinal Chemistry. 97: 561–81. doi:10.1016/j.ejmech.2014.10.085. PMID 26015069.
^Khanam H (June 2015). "Bioactive Benzofuran derivatives: A review". European Journal of Medicinal Chemistry. 97: 483–504. doi:10.1016/j.ejmech.2014.11.039. PMID 25482554.
^Nugteren-van Lonkhuyzen JJ, van Riel AJ, Brunt TM, Hondebrink L (December 2015). "Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans". Drug and Alcohol Dependence. 157: 18–27. doi:10.1016/j.drugalcdep.2015.10.011. PMID 26530501.
^Liu C, Jia W, Qian Z, Li T, Hua Z (February 2017). "Identification of five substituted phenethylamine derivatives 5-MAPDB, 5-AEDB, MDMA methylene homolog, 6-Br-MDMA, and 5-APB-NBOMe". Drug Testing and Analysis. 9 (2): 199–207. doi:10.1002/dta.1955. PMID 26856255.
^Barcelo B, Gomila I (2017). "Pharmacology and Literature Review Based on Related Death and Non-Fatal Case Reports of the Benzofurans and Benzodifurans Designer Drugs". Current Pharmaceutical Design. 23 (36): 5523–5529. doi:10.2174/1381612823666170714155140. PMID 28714411.
^Halberstadt AL, Chatha M, Stratford A, Grill M, Brandt SD (January 2019). "Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran ("FLY") and benzodifuran ("DragonFLY") analogs". Neuropharmacology. 144: 368–376. doi:10.1016/j.neuropharm.2018.10.037. PMC 6863604. PMID 30385253.
^Roque Bravo R, Carmo H, Carvalho F, Bastos ML, Dias da Silva D (August 2019). "Benzo fury: A new trend in the drug misuse scene". Journal of Applied Toxicology. 39 (8): 1083–1095. doi:10.1002/jat.3774. PMID 30723925. S2CID 73433890.
and 21 Related for: Substituted benzofuran information
The substitutedbenzofurans are a class of chemical compounds based on the heterocyclyc and polycyclic compound benzofuran. Many medicines use the benzofuran...
various dienophiles: Cycloisomerization of alkyne ortho-substituted phenols: Substitutedbenzofurans Dibenzofuran, an analog with a second fused benzene ring...
known with alternative substitutions: 2Cs, 25-NB Substituted amphetamines SubstitutedbenzofuransSubstituted cathinones Substituted methylenedioxyphenethylamines...
cyclisation gives the heterocycle benzofuran (coumarone). The first step in this reaction to the substitutedbenzofuran is called the Rap–Stoermer condensation...
of substituted α-alkyltryptamines List of substituted amphetamines List of substitutedbenzofurans List of substituted cathinones List of substituted...
to illicit use as designer drugs. Substituted amphetamine SubstitutedbenzofuranSubstituted cathinone Substituted methylenedioxyphenethylamine List of...
six-membered pyrrole and five-membered pyridine, both of which have a substituted nitrogen Polycyclic aromatic hydrocarbons, also known as polynuclear...
ALPHA Dimemebfe Efavirenz Glaucine Lorcaserin M-ALPHA RH-34 Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substitutedbenzofurans)....
ALPHA Dimemebfe Efavirenz Glaucine Lorcaserin M-ALPHA RH-34 Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substitutedbenzofurans)....
ALPHA Dimemebfe Efavirenz Glaucine Lorcaserin M-ALPHA RH-34 Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substitutedbenzofurans)....
known as '4-EMC' 3-Methylmethcathinone, also known as '3-MMC' Substitutedbenzofurans 5-APB 6-APB 5-APDB 6-APDB 5-MAPB 5-MAPDB 6-MAPDB, its psychedelic...
ALPHA Dimemebfe Efavirenz Glaucine Lorcaserin M-ALPHA RH-34 Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substitutedbenzofurans)....
ALPHA Dimemebfe Efavirenz Glaucine Lorcaserin M-ALPHA RH-34 Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substitutedbenzofurans)....
ALPHA Dimemebfe Efavirenz Glaucine Lorcaserin M-ALPHA RH-34 Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substitutedbenzofurans)....
ALPHA Dimemebfe Efavirenz Glaucine Lorcaserin M-ALPHA RH-34 Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substitutedbenzofurans)....
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