Subacute cutaneous lupus erythematosus information
Medical condition
Subacute cutaneous lupus erythematosus
Other names
SCLE
Specialty
Dermatology
Not to be confused with Lupus erythematosus panniculitis or Lupus erythematosus.
Subacute cutaneous lupus erythematosus (SCLE ) is a clinically distinct subset of cases of lupus erythematosus that is most often present in white women aged 15 to 40, consisting of skin lesions that are scaly and evolve as poly-cyclic annular lesions or plaques similar to those of plaque psoriasis.[1]
Characteristically the lesions appear in sun-exposed areas such as the vee of the neckline or the forearms, but not the face. It may be brought on by sun-sensitizing medications, but is usually associated with autoimmune disorders such as rheumatoid arthritis and Sjögren's syndrome.[2]
Therapy generally involves sun avoidance and protection and topical corticosteroids.[2] Sometimes systemic drug treatment is necessary. Besides corticosteroids other immunosuppressants such as methotrexate are also used.[3]
Lesions of SCLE may have an annular (shaped like a ring) configuration, with raised red borders and central clearing.[4][5]
^James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 160. ISBN 0-7216-2921-0.
^ abBurkhalter NW, McKenzie JT, Lane JE (2009). "Subacute cutaneous lupus erythematosus". Consultant. 49 (3).
^Boehm IB, Boehm GA, Bauer R (1998). "Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms". Rheumatology International. 18 (2): 59–62. doi:10.1007/s002960050058. PMID 9782534.
^Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 563. ISBN 978-1-4160-2999-1.
^Sontheimer RD, Thomas JR, Gilliam JN (December 1979). "Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset". Arch Dermatol. 115 (12): 1409–15. doi:10.1001/archderm.1979.04010120007006. PMID 533284.
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