Structural genomics seeks to describe the 3-dimensional structure of every protein encoded by a given genome. This genome-based approach allows for a high-throughput method of structure determination by a combination of experimental and modeling approaches. The principal difference between structural genomics and traditional structural prediction is that structural genomics attempts to determine the structure of every protein encoded by the genome, rather than focusing on one particular protein. With full-genome sequences available, structure prediction can be done more quickly through a combination of experimental and modeling approaches, especially because the availability of large number of sequenced genomes and previously solved protein structures allows scientists to model protein structure on the structures of previously solved homologs.
Because protein structure is closely linked with protein function, the structural genomics has the potential to inform knowledge of protein function. In addition to elucidating protein functions, structural genomics can be used to identify novel protein folds and potential targets for drug discovery. Structural genomics involves taking a large number of approaches to structure determination, including experimental methods using genomic sequences or modeling-based approaches based on sequence or structural homology to a protein of known structure or based on chemical and physical principles for a protein with no homology to any known structure.
As opposed to traditional structural biology, the determination of a protein structure through a structural genomics effort often (but not always) comes before anything is known regarding the protein function. This raises new challenges in structural bioinformatics, i.e. determining protein function from its 3D structure.
Structural genomics emphasizes high throughput determination of protein structures. This is performed in dedicated centers of structural genomics.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. On the other hand, the scientific value of some resultant structures is at times questioned. A Science article from January 2006 analyzes the structural genomics field.[1]
One advantage of structural genomics, such as the Protein Structure Initiative, is that the scientific community gets immediate access to new structures, as well as to reagents such as clones and protein. A disadvantage is that many of these structures are of proteins of unknown function and do not have corresponding publications. This requires new ways of communicating this structural information to the broader research community. The Bioinformatics core of the Joint center for structural genomics (JCSG) has recently developed a wiki-based approach namely Open protein structure annotation network (TOPSAN) for annotating protein structures emerging from high-throughput structural genomics centers.
^Chandonia JM, Brenner SE (January 2006). "The impact of structural genomics: expectations and outcomes". Science. 311 (5759): 347–51. Bibcode:2006Sci...311..347C. doi:10.1126/science.1121018. PMID 16424331. S2CID 800902.
and 27 Related for: Structural genomics information
The principal difference between structuralgenomics and traditional structural prediction is that structuralgenomics attempts to determine the structure...
The principal difference between structuralgenomics and traditional structural prediction is that structuralgenomics attempts to determine the structure...
structures of proteins representing every possible fold is known as structuralgenomics. Discovering the tertiary structure of a protein, or the quaternary...
The StructuralGenomics Consortium (SGC) is a public-private-partnership focusing on elucidating the functions and disease relevance of all proteins encoded...
RCSB PDB, and BMRB). The PDB is a key in areas of structural biology, such as structuralgenomics. Most major scientific journals and some funding agencies...
The TB StructuralGenomics Consortium (TBSGC) is a worldwide consortium of scientists developing a foundation for tuberculosis diagnosis and treatment...
to assess the model's quality. Structural alignments are especially useful in analyzing data from structuralgenomics and proteomics efforts, and they...
Functional genomics is a field of molecular biology that attempts to describe gene (and protein) functions and interactions. Functional genomics make use...
high-quality structural models when the target and template are closely related, which has inspired the formation of a structuralgenomics consortium dedicated...
tertiary structure for each sequence cluster is the aim of many structuralgenomics initiatives. CD-HIT UCLUST in USEARCH Starcode: a fast sequence clustering...
function made crystal clear - annotation of hypothetical proteins via structuralgenomics". Curr Opin Biotechnol. 11 (1): 25–30. doi:10.1016/j.exppara.2015...
is a noted Canadian molecular biologist, and the director of the StructuralGenomics Consortium. ReGenesis has been an international pioneer in integrating...
Genomicstructural variation is the variation in structure of an organism's chromosome, such as deletions, duplications, copy-number variants, insertions...
such as the Human Genome Project. Despite community-wide efforts in structuralgenomics, the output of experimentally determined protein structures—typically...
Bioinformatics plays a key role in various areas, such as functional genomics, structuralgenomics, and proteomics, and forms a key component in the biotechnology...
was a USA based project that aimed at accelerating discovery in structuralgenomics and contribute to understanding biological function. Funded by the...
Chemicals San Diego Center for Chemical Genomics SGCOxCompounds, SGCStoCompounds SMID Specs StructuralGenomics Consortium SureChem Synthon-Lab Thomson...
OC (born June 1, 1962) is the founder and Chief Executive of the StructuralGenomics Consortium, a charitable public-private partnership. He is Professor...
cyclase (sGC) Standard Geographical Classification code (Canada) StructuralGenomics Consortium Salivary gland carcinoma, a type of oral cancer Swan-Ganz...
composition in different evolutionary lineages. See also: History of genomics Comparative genomics has a root in the comparison of virus genomes in the early 1980s...
comparing sequence-based and structure-based families: implications for structuralgenomics and function annotation in genomes". Nucleic Acids Research. 30 (1):...
Computational genomics is the study of the genomes of cells and organisms. The Human Genome Project is one example of computational genomics. This project...