Histologic image showing a section of epidermis. Stratum granulosum labeled near center.
The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis lying above the stratum spinosum and below the stratum corneum (stratum lucidum on the soles and palms).[1] Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer. These cells contain keratohyalin granules, which are filled with histidine- and cysteine-rich proteins that appear to bind the keratin filaments together.
Therefore, the main function of keratohyalin granules is to bind intermediate keratin filaments together.[2][3]
At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space. This results in the formation of the hydrophobic lipid envelope responsible for the skin's barrier properties. Concomitantly, cells lose their nuclei and organelles.
^James, William; Berger, Timothy; Elston, Dirk (2005) Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Page 2. ISBN 0-7216-2921-0.
^Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. Page 7. ISBN 1-4160-3185-5.
^Ovaere P; Lippens S; Vandenabeele P; Declercq W. (2009). "The emerging roles of serine protease cascades in the epidermis". Trends in Biochemical Sciences. 34 (9): 453–463. doi:10.1016/j.tibs.2009.08.001. PMID 19726197.
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The stratumgranulosum (or granular layer) is a thin layer of cells in the epidermis lying above the stratum spinosum and below the stratum corneum (stratum...
keratinocytes are moving through the stratum spinosum and stratumgranulosum.[citation needed] The thickness of the stratum lucidum is controlled by the rate...
cell to journey from the stratum basale to the top of the stratumgranulosum, and an additional four weeks to cross the stratum corneum. The entire epidermis...
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exposed after top layers of the epidermis (stratum corneum, stratumgranulosum, stratum spinosum and stratum basale) have been removed. This is often uncomfortable...
structure found in cytoplasmic granules of the keratinocytes in the stratumgranulosum of the epidermis. Keratohyalin granules (KHG) mainly consist of keratin...
the stratumgranulosum. Profilaggrin undergoes proteolytic processing to yield individual filaggrin monomers at the transition between the stratum granulosum...
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corneodesmosome connections must be degraded. Keratinocytes residing in the stratumgranulosum produce corneodesmosome-degrading kallikrein family members, especially...
desmoglein I, a cadherin (adhesion protein) in the desmosomes of the stratumgranulosum that facilitates intercellular adhesion between keratinocytes. The...
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suprabasally as they become part of the stratum spinosum, stratumgranulosum, and eventually corneocytes in the stratum corneum. Corneocytes are keratinocytes...
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pass through this stratum on the way to CA3. Stratumgranulosum (str. gr.) contains the cell bodies of the dentate granule cells. Stratum moleculare, inner...
epithelium with several strata: the stratum corneum, stratum lucidum, stratumgranulosum, stratum spinosum, and stratum basale. Nourishment is provided to...
in the upper part of stratum spinosum. From the site of production, lamellar bodies migrate to the top of the stratumgranulosum and then into the intercellular...
epithelium with several strata: the stratum corneum, stratum lucidum, stratumgranulosum, stratum spinosum, and stratum basale. Nourishment is provided to...
lipids secreted by the stratumgranulosum just underneath, which help to make this layer of the skin a waterproof barrier. The stratum corneum's function...
layer): Stratum corneum Stratum lucidum (only in palms and soles) StratumgranulosumStratum spinosum Stratum basale (also called the stratum germinativum)...
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another characteristic histologic finding of psoriasis lesions. The stratumgranulosum layer of the epidermis is often missing or significantly decreased...
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frequently found in the skin. They penetrate the dermis and end in the stratumgranulosum. FNEs infiltrate the middle layers of the dermis and surround hair...
the exterior portion of the Malpighian layer of the epidermis, the stratumgranulosum otherwise known as the Layer of Langerhans. Langerin – CD207, langerin...
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