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Stem bromelain
Identifiers
EC no.
3.4.22.32
CAS no.
37189-34-7
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IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
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KEGG
KEGG entry
MetaCyc
metabolic pathway
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PDB structures
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proteins
Stem bromelain (SBM) (EC 3.4.22.32), a proteolytic enzyme, is a widely accepted phytotherapeutical drug member of the bromelain family of proteolytic enzymes obtained from Ananas comosus.[1] Some of the therapeutic uses of SBM are reversible inhibition of platelet aggregation, angina pectoris, bronchitis, sinusitis, surgical traumas, thrombophlebitis, pyelonephritis and enhanced absorption of drugs, particularly of antibiotics. Its anti-metastasis and anti-inflammatory activities are apparently independent of its proteolytic activity. Although poorly understood, the diverse pleiotrophic effects of SBM seem to depend on its ability to traverse the membrane barrier, a very unusual property of this protein.
^Schomburg D, Stephan D (1998). "Stem bromelain". Enzyme Handbook. Vol. 16. Heidelberg: Springer, Berlin. pp. 51–58. doi:10.1007/978-3-642-58903-4_9. ISBN 978-3-642-58903-4.
Bromelain is an enzyme extract derived from the stems of pineapples, although it exists in all parts of the fresh plant and fruit. The extract has a history...
Stembromelain (SBM) (EC 3.4.22.32), a proteolytic enzyme, is a widely accepted phytotherapeutical drug member of the bromelain family of proteolytic...
and some properties of the proteolytically active components of stem and fruit bromelains". Journal of Biochemistry. 98 (1): 219–28. PMID 4044551. Rowan...
Ananain (EC 3.4.22.31, stembromelain, fruit bromelain) is an enzyme. This enzyme catalyses the following chemical reaction Hydrolysis of proteins with...
pineapple plant, bromelain is a mixture of proteolytic enzymes. It is present in stem, fruit, crown, core, leaves of pineapple itself. Bromelain is under preliminary...
and on amino acid sequence information for cathepsins B and H, and stembromelain". Journal of Molecular Biology. 182 (2): 317–329. doi:10.1016/0022-2836(85)90348-1...
exist. It has long been known in animal studies that bromelain, a substance obtained from the stems and leaves of the pineapple plant, suppresses trauma-induced...
Procumbens DC. Ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in in Vitro Models of Inflammation...
distantly related papain derived from papaya latex, bromelase (bromelain) extracted from pineapple stem, calpain, caspases, cathepsin B, and chymopapain. Cysteine...
although expression is very low. Exposure to some compounds such as bromelain, Bortezomib, estrogen, and 4-hydroxytamoxifen lead to increase in C15orf32...
commercially important food crop. Bromelain, a common ingredient in meat tenderizer, is extracted from pineapple stems. Many other bromeliads are popular...
hemagglutinin esterase fusion trimer using X-ray crystallography of the bromelain-cleaved ectodomain. Both hemagglutinin and hemagglutinin esterase fusion...
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