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Split and pool synthesis information


The split and pool (split-mix) synthesis is a method in combinatorial chemistry that can be used to prepare combinatorial compound libraries. It is a stepwise, highly efficient process realized in repeated cycles. The procedure makes it possible to prepare millions or even trillions of compounds as mixtures that can be used in drug research.

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Split and pool synthesis

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The split and pool (split-mix) synthesis is a method in combinatorial chemistry that can be used to prepare combinatorial compound libraries. It is a stepwise...

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Combinatorial chemistry

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actual synthesis, based upon various calculations and criteria (see ADME, computational chemistry, and QSAR). Combinatorial split-mix (split and pool) synthesis...

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Nucleotide

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(November 1992). "Contribution of de-novo and salvage synthesis to the uracil nucleotide pool in mouse tissues and tumors in vivo". European Journal of Biochemistry...

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Electron transport chain

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drives the synthesis of ATP via coupling with oxidative phosphorylation with ATP synthase. In eukaryotic organisms, the electron transport chain, and site of...

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Methanol

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convert synthesis gas (a mixture of carbon monoxide, carbon dioxide, and hydrogen) into methanol and received a patent. According to Bozzano and Manenti...

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Sodium

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phosphoenolpyruvate and synthesis of chlorophyll. In others, it substitutes for potassium in several roles, such as maintaining turgor pressure and aiding in the...

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Linguistics in science fiction

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speech, which is completely produced by the machine itself and is the form of speech synthesis portrayed by Robert A. Heinlein in The Moon is a Harsh Mistress...

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Darwinism

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development of the modern synthesis in the early 20th century, incorporating natural selection with population genetics and Mendelian genetics, revived...

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Light skin

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and extremely light skin is prevalent. The gene variation's primary effect is to promote eumelanin synthesis at the expense of pheomelanin synthesis,...

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Western Steppe Herders

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Early European Farmers (EEFs) from the European gene pool, significantly altering the cultural and genetic landscape of Europe. During the Bronze Age,...

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Register allocation

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Proceedings of the 14th international conference on Compilers, architectures and synthesis for embedded systems - CASES '11. p. 25. doi:10.1145/2038698.2038706...

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Gene

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types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of RNA or protein from a gene), DNA is first...

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Millennium Biltmore Hotel

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designed the Biltmore's exterior in a synthesis of the Spanish-Italian Renaissance Revival, Mediterranean Revival, and Beaux Arts styles, meant as an homage...

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Thylakoid

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electron transport chain of the photosystems and cytochrome complex, and ATP synthesis by the ATP synthase utilizing the generated proton gradient. The first...

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FripSide

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Phase 3's two new singers, Mao Uesugi and Hisayo Abe. Phase 2 singer, Yoshino Nanjo, performed "infinite synthesis" then was joined by Phase 3's singers...

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Mary Kay Letourneau

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1973, Philip Schmitz, one of Mary's Kay's brothers, drowned in the family pool at their home in the Spyglass Hill section of Corona del Mar, California...

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Human genome

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the many reactions of protein synthesis and RNA processing. Noncoding RNA include tRNA, ribosomal RNA, microRNA, snRNA and other non-coding RNA genes including...

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Petra

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which included a large swimming pool, an island-pavilion, and an intricate hydraulic system. Ahead of the Petra Pool and Garden Complex lies Colonnaded...

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East Slavs

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Y-хромосомы [Variability of the gene pool in space and time: synthesis of data on the genogeography of mitochondrial DNA and Y-chromosome] (PDF) (Dr. habil...

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LSD

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5S stereoisomers of lysergamides do not exist in nature and are not formed during the synthesis from d-lysergic acid. Retrosynthetically, the C-5 stereocenter...

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IG Farben

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the polyaddition for the synthesis of polyurethane in 1937, and three company scientists became Nobel laureates: Carl Bosch and Friedrich Bergius in 1931...

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List of TCP and UDP port numbers

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Retrieved 2016-08-27. "Basic command line options". The Festival Speech Synthesis System – System documentation (1.4 ed.). University of Edinburgh (published...

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List of PlayStation VR2 games

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#BigShotsVR 💥". X (formerly Twitter). Retrieved 2023-11-07. "Black Hole Pool". store.playstation.com. Retrieved 2023-04-18. Barker, Sammy (2022-07-20)...

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Mitochondrial fission

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mitochondria. Actin bundles are reservoirs of Drp1 proteins and their polymerization helps enable provide a pool of Drp1 proteins to assemble onto the mitochondria...

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AV1

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of another patent pool). For example, Alliance members Apple, Cisco, Google, and Microsoft are also licensors in MPEG-LA's patent pool for H.264. As an...

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Genetic history of North Africa

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both southern Qahtanite and northern Adnanite Arabs added to the heterogenous Maghrebi ethnic melting pot. The Eu10 chromosome pool in the Maghreb is derived...

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