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Spidroin, N-terminal
Identifiers
Symbol
Spidroin_N
Pfam
PF16763
InterPro
IPR031913
CATH
2lpj
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Spidroin, C-terminal
Identifiers
Symbol
Spidroin_MaSp
Pfam
PF11260
InterPro
IPR021001
CATH
2m0m
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Spidroin-1
Identifiers
Organism
Nephila clavipes
Symbol
?
UniProt
P19837
Search for
Structures
Swiss-model
Domains
InterPro
Spidroin-2
Identifiers
Organism
Nephila clavipes
Symbol
?
UniProt
P46804
Search for
Structures
Swiss-model
Domains
InterPro
A diagram of the structure of spidroin
Spidroins are the main proteins in spider silk. Different types of spider silk contain different spidroins, all of which are members of a single protein family.[1] The most-researched type of spidroins are the major ampullate silk proteins (MaSp) used in the construction of dragline silk, the strongest type of spider silk. Dragline silk fiber is made up of two types of spidroins, spidroin-1 (MaSp1) and spidroin-2 (MaSp2).[2][3]
Spidroin is part of a large group of proteins called scleroproteins. This group includes other insoluble structural proteins such as collagen and keratin.
A fiber of dragline spidroin is as thick and resistant as one of steel but is more flexible. It can be stretched to approximately 135% of its original length without breaking.
Its properties make it an excellent candidate for use in various scientific fields.[4]
^Cite error: The named reference acsp1 was invoked but never defined (see the help page).
^Motriuk-Smith D, Smith A, Hayashi CY, Lewis RV (2005). "Analysis of the conserved N-terminal domains in major ampullate spider silk proteins". Biomacromolecules. 6 (6): 3152–9. doi:10.1021/bm050472b. PMID 16283740.
^Moisenovich MM, Pustovalova O, Shackelford J, Vasiljeva TV, Druzhinina TV, Kamenchuk YA, Guzeev VV, Sokolova OS, Bogush VG, Debabov VG, Kirpichnikov MP, Agapov II (May 2012). "Tissue regeneration in vivo within recombinant spidroin 1 scaffolds". Biomaterials. 33 (15): 3887–98. doi:10.1016/j.biomaterials.2012.02.013. PMID 22364702.
^Askarieh G, Hedhammar M, Nordling K, Saenz A, Casals C, Rising A, Johansson J, Knight SD (May 2010). "Self-assembly of spider silk proteins is controlled by a pH-sensitive relay". Nature. 465 (7295): 236–8. Bibcode:2010Natur.465..236A. doi:10.1038/nature08962. PMID 20463740. S2CID 4366005.
Spidroins are the main proteins in spider silk. Different types of spider silk contain different spidroins, all of which are members of a single protein...
flagelliform spidroins, called Flag; tubuliform spidroins, called TuSp; aciniform spidroins, called AcSp; aggregate spidroins, called AgSp; pyriform spidroins, called...
structure. The primary structure is the amino acid sequence of its proteins (spidroin), mainly consisting of highly repetitive glycine and alanine blocks, which...
revealed 28 unique genes for the proteins comprising spider silk, known as spidroins. Furthermore, the silk of T. clavipes has the potential to aid in surgeries...
were found to be 20,167 protein-coding genes, including 55 toxin and 26 spidroin (spider silk) genes. "Taxon details Latrodectus elegans Thorell, 1898"...
Researchers report that they succeeded in using a genetically-altered variant of R. sulfidophilum to produce spidroins, the main proteins in spider silk....
in various species of Pseudomonas Chaplins from Streptomyces coelicolor Spidroin from Trichonephila edulis (spider) (Spider silk) Hydrophobins from Neurospora...
grow new tissues. She has patented the synthesised silk (functionalised spidroin). Goodacre created the app Spider in da House. She works to make people...
in using a genetically altered variant of R. sulfidophilum to produce spidroins, the main proteins in spider silk. 10 July – Scientists report that after...
A process to mass-produce an analogue called rSP-C33Le by fusion with spidroin has been described. GRCh38: Ensembl release 89: ENSG00000168484 – Ensembl...
2016. Her UC Riverside laboratory's work characterized spiders in the spidroin gene family, including how silk is encoded and studying the basis of molecular...
produce 4RepCT proteins that have a higher cell adhesion than natural spidroin proteins and have varied antimicrobial properties. The second method, chemical...
sulfidophilum can produce the hydrophobic repetitive sequence of major ampullate spidroin (MaSp), the major protein in spider silk. After constructing a plasmid...
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