Global InformationSolitary mastocytoma information
| Solitary mastocytoma | |
|---|---|
| Other names | Cutaneous mastocytoma |
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| Solitary mastocytoma. | |
| Specialty | Dermatology, oncology  |
Solitary mastocytoma, also known as cutaneous mastocytoma, may be present at birth or may develop during the first weeks of life, originating as a brown macule that urticates on stroking.[1]: 615 Solitary mastocytoma is a round, erythematous, indurated lesion measuring 1-5 cm in diameter. It can be mildly itchy or asymptomatic and develops over time. Predilection is the head and neck, followed by the trunk, extremities, and flexural areas.
About 40% of children with cutaneous mastocytosis have exon 17 KIT mutations, while 40% have other exon mutations. Stem cell factor expression is increased in some cases, and solitary cutaneous mastocytomas have been reported at trauma sites.
The diagnosis of solitary mastocytoma is primarily clinical, with skin biopsy confirming a KIT mutation and mast cell infiltration. Treatments are symptomatic, with oral H1 antihistamines being the mainstay. Preventative measures include air conditioning, lukewarm water, and avoiding triggers.
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.