In manufacturing, the simulated moving bed (SMB) process is a highly engineered process for implementing chromatographic separation. It is used to separate one chemical compound or one class of chemical compounds from one or more other chemical compounds to provide significant quantities of the purified or enriched material at a lower cost than could be obtained using simple (batch) chromatography. It cannot provide any separation or purification that cannot be done by a simple column purification. The process is rather complicated. The single advantage which it brings to a chromatographic purification is that it allows the production of large quantities of highly purified material at a dramatically reduced cost. The cost reductions come about as a result of: the use of a smaller amount of chromatographic separation media stationary phase, a continuous and high rate of production, and decreased solvent and energy requirements. This improved economic performance is brought about by a valve-and-column arrangement that is used to lengthen the stationary phase indefinitely and allow very high solute loadings to the process.
In the conventional moving bed technique of production chromatography the feed entry and the analyte recovery are simultaneous and continuous, but because of practical difficulties with a continuously moving bed, the simulated moving bed technique was proposed. In the simulated moving bed technique instead of moving the bed, the feed inlet, the solvent or eluent inlet and the desired product exit and undesired product exit positions are moved continuously, giving the impression of a moving bed, with continuous flow of solid particles and continuous flow of liquid in the opposite direction of the solid particles.[1][2]
True moving bed chromatography (TMBC) is only a theoretical concept. Its simulation, SMBC, is achieved by the use of a multiplicity of columns in series and a complex valve arrangement, which provides for flow of the feed mixture and solvent, and "eluent" or "desorbent" feed at any column. The valving and piping arrangements and the predetermined control of these allow switching at regular intervals the sample entry in one direction, the solvent entry in the same direction but at a different location in the continuous loop, whilst changing the fast product and slow product takeoff positions to also move in the same direction, but at different relative locations within the loop. [3]
Ref 3 explains that the advantage of the SMBC is high production rate, because a system could be near continuous, whilst its disadvantage is that it only performs one cut in mixtures. Thus, it is well-suited for separation of a binary mixture. With multiple cuts, analogous to a series of distillation columns, multiple compounds can be separated from a mixture of more than two compounds. With regard to efficiency it compares with the simple chromatography technique like continuous distillation does with batch distillation.
^Bailly, M. and Nicoud, R.-M. (LSGC-ENSIC, 1, rue Grandville, 54001 Nancy and SEPAREX, 5, rue Monod, 54250, Champigneulle, France): The simulated moving bed: a powerful process for purification
^Rivat, C. and Stoltz, J.F. (Institut national de la santé et de la recherche médicale (France)) (1993). Biotechnology of Blood Proteins — Purification, Clinical and Biological Applications. John Libbey Eurotext. ISBN 2-7420-0007-0.{{cite book}}: CS1 maint: multiple names: authors list (link)
^"What is simulated moving bed chromatography (SMB chromatography)?" (PDF). Retrieved May 7, 2008.
and 27 Related for: Simulated moving bed information
In manufacturing, the simulatedmovingbed (SMB) process is a highly engineered process for implementing chromatographic separation. It is used to separate...
a continuously movingbed, simulatedmovingbed technique was proposed. In the simulatedmovingbed technique instead of moving the bed, the sample inlet...
high-molecular-weight hydrocarbons. For manufacturing, efficient preparative simulatedmovingbed units are available. The purity of the final products is very high...
communication Server Message Block (SMB or SMB/CIFS), a network protocol Simulatedmovingbed for chromatographic separation Surface marker buoy, to indicate a...
ISSN 0021-9673. Negawa M, Shoji F (1992-01-24). "Optical resolution by simulatedmoving-bed adsorption technology". Journal of Chromatography A. Eight International...
S2CID 135570958. Cong J, Lin B (March 2007). "Separation of Liquiritin by simulatedmovingbed chromatography". Journal of Chromatography A. 1145 (1–2): 190–4....
inhibitors, but must be separated from the sugar stream for recycle [simulatedmovingbed chromatographic separation, for example] to be commercially attractive...
types of chromatographical separation, such as standard column, simulatedmoving-bed (SMB) or supercritical fluid (SCF) techniques. For peptides three...
“Eliminating the downstream processing bottleneck with monoliths and simulatedmovingbed chromatography.” Pete Gagnon, BioProcess International, September...
through chromatographic separation, using techniques such as the "simulatedmovingbed". The processing of beet produces large amounts of water; beet as...
software package used for both batch chromatography and chromatography simulatedmovingbed processes. Aspen Properties- It is useful for the thermophysical...
countercurrent processes. An established process of this kind is the simulatedmovingbed technique (SMB) that requires the solvent-consuming steps of equilibration...
A seagrass meadow or seagrass bed is an underwater ecosystem formed by seagrasses. Seagrasses are marine (saltwater) plants found in shallow coastal waters...
a cover version of the Beatles' song "Michelle", and recorded several simulated sexual encounters, including an example of phone sex, a threesome, and...
glacier bed friction was almost as important as the future ocean temperature. Another finding was that lower-resolution models (those which simulated the...
than the bed, which means that as the tool bit moves, the follower rest "follows along" (because they are both rigidly connected to the same moving carriage)...
translation over simulated Mars soil, 40 seconds of hover at the apex, and a slant descent to "landing" using free flight guidance. The Mars simulated soil was...
meets the more outgoing Kelly (Gugu Mbatha-Raw). The town is part of a simulated reality the elderly can inhabit, even after death. "San Junipero" was...
minutes later, two Sukhoi Su-24 jets make 11 low-level passes matching a simulated attack profile. 13 April A Sunbird Aviation Britten-Norman BN-2T Turbine...
directing each other to resources while exploring their environment. The simulated 'ants' similarly record their positions and the quality of their solutions...
1974 and 1978. Bundy's true victim total is unknown. Bundy typically simulated having a physical impairment such as an injury to convince his target...
picks Maynard for the experiment which requires him to spend 30 days in a simulated space capsule. Maynard will be teamed with Corporal Kilroy who happens...
does not touch us as an audience. Aristotle holds that it is through "simulated representation," mimesis, that we respond to the acting on the stage,...
side-effects. It began on the British television network Channel 4 before moving to the American streaming platform Netflix and has run for six series between...
Petroglyph. Vitlycke, Sweden. Bronze-age. Sex between a female and a male on a bed. Clay model. Old Babylonian, around 1800 BCE. Sex between a female and a...
caused the primary circuit to undergo the same safe shutdown. This test simulated the case of a water-cooled reactor losing its steam turbine circuit, perhaps...
during White Nights, after a "revolutionary suicide" vote was reached, a simulated mass suicide was rehearsed. Temple defector Deborah Layton described the...
Global Information