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Medical condition
Senger's syndrome
Other names
Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome, Cardiomyopathy and cataract.
Autosomal recessive pattern is the inheritance manner of this condition
Symptoms
Cataracts, fatigue, muscle weakness, hypotonia, lactic acidosis, and cardiomyopathy.[1]
Usual onset
Birth
Causes
Mutations in the AGK and SLC25A4 genes.[2]
Frequency
Rare
Sengers syndrome is a rare autosomal recessive mitochondrial disease characterised by congenital cataract, hypertrophic cardiomyopathy, muscle weakness and lactic acidosis after exercise.[3] Biallelic pathogenic mutations in the AGK gene, which encodes the acylglycerol kinase enzyme, cause Sengers syndrome.[2] In addition, heart disease and muscle disease are prevalent, meaning that life expectancy is short for many patients.[1]
of Anneke and Jan R. C. A. Sengers, Dutch medical researcher, namesake of SengerssyndromeSenger, German surname Sengers Ladies Cycling Team, Belgian...
electrocardiogram (ECG/EKG), both for stable angina and acute coronary syndrome. An X-ray of the chest, blood tests and resting echocardiography may be...
kidney disease. It is associated with a group of congenital fibrocystic syndromes. Mutations in the PKHD1 (chromosomal locus 6p12.2) cause ARPKD. Symptoms...
whether it can reduce the risk of diet-related diseases, such as metabolic syndrome. A 2019 review concluded that intermittent fasting may help with obesity...
cocaine, significant emotional stress (often known as Takotsubo syndrome or broken heart syndrome) and extreme cold, among others. Many tests are helpful to...
point for most health care purposes. This classification treats HELLP syndrome as a type of preeclampsia rather than a parallel entity. Chronic hypertension...
Talismans from the Islamic World". The Metropolitan Museum of Art. Gerda Sengers Women and Demons: Cultic Healing in Islamic Egypt BRILL 2003 ISBN 978-9-004-12771-5...
secondary to high blood pressure or hypertension Heart failure – a clinical syndrome caused by the inability of the heart to supply sufficient blood to the...
organs. Rapid growth can lead to metabolic disorders such as sudden death syndrome and ascites. Breeding for increased breast muscle affects the way chickens...
Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal...
alkaptonuria and in people with melanoma. Purple urine occurs in purple urine bag syndrome. A spectrum of abnormal colors can result from the intake of drugs. An...
2019-09-18. Huber, M. L.; Perkins, R. A.; Laesecke, A.; Friend, D. G.; Sengers, J. V.; Assael, M. J.; Metaxa, I. N.; Vogel, E.; Mareš, R.; Miyagawa, K...
Ceremonies . London, UK: W.H.Allen. pp. 134–6. Retrieved 4 October 2019. Gerda Sengers Women and Demons: Cultic Healing in Islamic Egypt BRILL, 2003 ISBN 978-90-04-12771-5...
"Autoantibodies to folate receptors in the cerebral folate deficiency syndrome". The New England Journal of Medicine. 352 (19): 1985–91. doi:10.1056/NEJMoa043160...
doi:10.1152/physrev.00020.2012. PMC 3962546. PMID 23899562. Stirrat LI, Sengers BG, Norman JE, Homer NZ, Andrew R, Lewis RM, Reynolds RM (February 2018)...
original on 5 July 2014. Retrieved 14 July 2014. Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP (December 2013). "Vitamin and mineral supplements...
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