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Selamectin information


Selamectin
Clinical data
Trade namesRevolution, Stronghold, Revolt
Other names25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide[1]
AHFS/Drugs.comInternational Drug Names
License data
  • US DailyMed: Selamectin
Routes of
administration
Topical
ATCvet code
  • QP54AA05 (WHO) QP53BX55 (WHO)
Legal status
Legal status
  • US: ℞-only[2]
  • EU: Rx-only[3]
Identifiers
CAS Number
  • 220119-17-5 ☒N
PubChem CID
  • 9578507
ChemSpider
  • 16738655 ☒N
UNII
  • A2669OWX9N
ChEMBL
  • ChEMBL160777 ☒N
CompTox Dashboard (EPA)
  • DTXSID6045903 Edit this at Wikidata
ECHA InfoCard100.250.168 Edit this at Wikidata
Chemical and physical data
FormulaC43H63NO11
Molar mass769.973 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7
InChI
  • InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1 ☒N
  • Key:AFJYYKSVHJGXSN-XHKIUTQPSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats.[2] It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.[citation needed] It is structurally related to ivermectin and milbemycin.[citation needed] Selamectin is not approved for human use.[citation needed]

  1. ^ Bishop BF, Bruce CI, Evans NA, Goudie AC, Gration KA, Gibson SP, et al. (August 2000). "Selamectin: a novel broad-spectrum endectocide for dogs and cats". Veterinary Parasitology. 91 (3–4): 163–176. doi:10.1016/s0304-4017(00)00289-2. PMID 10940519.{{cite journal}}: CS1 maint: overridden setting (link)
  2. ^ a b "Revolution- selamectin solution". DailyMed. 1 December 2023. Retrieved 6 February 2024.
  3. ^ "Evicto EPAR". European Medicines Agency. 1 August 2019. Retrieved 26 June 2024.

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Selamectin

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Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents...

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Ear mite

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mange mite) treatments currently use the antiparasitics ivermectin and selamectin, usually as topical preparations. Ivermectin is available as a direct...

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Mange

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as a fungicide must be diluted 1:16 or 1:32 for use on animal skin). Selamectin is licensed for treatment in dogs by veterinary prescription in several...

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Flea treatments

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insecticides. A comparison of 3 insecticides (selamectin, fipronil, imidacloprid) showed that selamectin reduced larval cat fleas ≥93.5% after 24 h at...

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Sarolaner

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antiparasitic Revolution Plus (or Stronghold Plus), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline...

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Dirofilaria immitis

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topical selamectin (Revolution for Cats) and Advantage Multi (imidacloprid + moxidectin) topical solution. Ivermectin, milbemycin, and selamectin are approved...

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Shetland Sheepdog

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erythromycin, ivermectin, loperamide, milbemycin, moxidectin, rifampin, selamectin, vinblastine, and vincristine. Ulcerative dermatosis of Shetland sheepdog...

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Cheyletiella

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the conclusion of symptoms. In unresponsive cases, ivermectin is used. Selamectin is also recommended for treatment. None of these products are approved...

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Toxocara canis

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example fenbendazole, milbemycin, moxidectin, piperazine, pyrantel, and selamectin. T. canis is dioecious, having morphology distinctly different between...

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Avermectin

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Other anthelmintics derived from the avermectins include ivermectin, selamectin, doramectin, eprinomectin. Half of the 2015 Nobel Prize in Physiology...

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Notoedric mange

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Certain antiparasitic drugs used to control Notoedric mange include selamectin, moxidectin, ivermectin and lime sulfur dips. Lime sulfur is most commonly...

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List of veterinary drugs

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coccidiostat and for increased weight gain sarolaner - antiparasitic selamectin – antiparasitic treating fleas, roundworms, ear mites, heartworm, and...

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Ancylostoma tubaeforme

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oral anthelmintics such as fenbendazole, or topical treatments such as selamectin. Feline zoonosis Taylor, MA; Coop, RL; Wall, RL, eds. (2015). "Superfamily...

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List of insecticides

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rotenone ryania ryanodine sabadilla sanguinarine sarolaner schradan selamectin semiamitraz [Wikidata] silafluofen silica gel sodium arsenite sodium cyanide...

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Moxidectin

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receptor avermectins Abamectin Doramectin Emamectin Eprinomectin Ivermectin# Selamectin milbemycins Moxidectin Milbemycin oxime NMDA tetrahydropyrimidine Pyrantel#...

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Otitis externa in animals

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drops that contain pyrethrins or an avermectin such as ivermectin or selamectin. Cleaning of the ears is very important for treatment of ear infections...

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Toxocariasis

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animal. Other effective treatments include ivermectin, milbemycin, and selamectin. Dichlorvos has also been proven to be effective as a poison, though moves...

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Mammomonogamus auris

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included topical thiabendazole/dexamethasone/neomycin ointment as well as selamectin. Edgar G. Tudor; Alice C. Y. Lee; Danielle G. Armato; Dwight D. Bowman...

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Ornithonyssus bacoti

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guinea pigs, etc.) may also suffer infestation. To rid pets of the mite, selamectin is generally used in the form of Revolution, Stronghold or Pfizer. Extermination...

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ATCvet code QP54

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QP54AA02 Abamectin QP54AA03 Doramectin QP54AA04 Eprinomectin QP54AA05 Selamectin QP54AA06 Emamectin QP54AA51 Ivermectin, combinations QP54AA52 Abamectin...

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Trichodectes canis

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treated according to typical lice infestations in dogs. Imidacloprid and selamectin administered is effective, as well as topical permethrin. Treatment of...

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Cat worm infections

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milbemycinoxime, moxidectin, pyrantel and selamectin are approved in Germany for domestic cats. Emodepside, eprinomectin, and selamectin may be used in pregnant and...

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Nematode infection in dogs

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flubendazole, mebendazole, milbemycin oxime, moxidectin, pyrantel and selamectin are approved in Germany for domestic dogs. These drugs are broad-spectrum...

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Gamasoidosis

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been used off-label to treat the condition, including sarolaner in dogs, selamectin in cats and permethrin in horses. Gamasoidosis, particularly caused by...

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Metaflumizone

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to be insignificant when compared with comparable treatments such as selamectin that do impact the mosquito disease vector. In 2011, Pfizer Animal Care...

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