SRPK1 information

SRPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WAK, 1WBP, 3BEG, 4WUA
Identifiers
Aliases	SRPK1, SFRSK1, SRSF protein kinase 1
External IDs	OMIM: 601939; MGI: 106908; HomoloGene: 110962; GeneCards: SRPK1; OMA:SRPK1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,841,683 bp
RNA expression pattern
	Top expressed in
	sperm; ; trabecular bone; ; bone marrow; ; secondary oocyte; ; endothelial cell; ; blood; ; bone marrow cells; ; human penis; ; rectum; ; thymus;
	Top expressed in
	tail of embryo; ; genital tubercle; ; morula; ; secondary oocyte; ; spermatid; ; zygote; ; spermatocyte; ; primary oocyte; ; primitive streak; ; seminiferous tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding; RNA binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; nuclear matrix; plasma membrane; endoplasmic reticulum; nucleus; cytosol;
Biological process	cell differentiation; intracellular signal transduction; phosphorylation; regulation of mRNA processing; chromosome segregation; mRNA processing; regulation of mRNA splicing, via spliceosome; protein phosphorylation; negative regulation of viral genome replication; RNA splicing; positive regulation of viral genome replication; innate immune response; viral process; sperm DNA condensation; spliceosomal complex assembly; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	6732
	20815
	n/a
	ENSMUSG00000004865
	Q96SB4
	O70551
	NM_003137
	NM_016795
	NP_003128
	NP_058075
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.^[4]^[5]^[6]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004865 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539.
^ Wang HY, Arden KC, Bermingham JR, Viars CS, Lin W, Boyer AD, Fu XD (May 1999). "Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes". Genomics. 57 (2): 310–5. doi:10.1006/geno.1999.5770. PMID 10198174.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000004865 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8208298-4] Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539.

[pmid10198174-5] Wang HY, Arden KC, Bermingham JR, Viars CS, Lin W, Boyer AD, Fu XD (May 1999). "Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes". Genomics. 57 (2): 310–5. doi:10.1006/geno.1999.5770. PMID 10198174.

[entrez-6] Cite error: The named reference entrez was invoked but never defined (see the help page).

SRPK1 information

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