SnRNP70 information

SNRNP70
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L5I, 2L5J, 3CW1, 3PGW, 4PJO, 4PKD
Identifiers
Aliases	SNRNP70, RNPU1Z, RPU1, SNRP70, Snp1, U1-70K, U170K, U1AP, U1RNP, SnRNP70, small nuclear ribonucleoprotein U1 subunit 70
External IDs	OMIM: 180740; MGI: 98341; HomoloGene: 20672; GeneCards: SNRNP70; OMA:SNRNP70 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,108,605 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,045,166 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; sural nerve; ; right uterine tube; ; right lobe of thyroid gland; ; left ovary; ; body of uterus; ; right ovary; ; left lobe of thyroid gland; ; canal of the cervix; ; body of pancreas;
	Top expressed in
	neural layer of retina; ; genital tubercle; ; tail of embryo; ; primary visual cortex; ; superior frontal gyrus; ; ventricular zone; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; mRNA binding; U1 snRNP binding; U1 snRNA binding; RNA binding;
Cellular component	nuclear speck; nucleoplasm; precatalytic spliceosome; spliceosomal complex; commitment complex; U2-type prespliceosome; nucleus; U1 snRNP; cytoplasm;
Biological process	mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; mRNA processing; negative regulation of chaperone-mediated autophagy; regulation of RNA splicing; RNA splicing; regulation of ATP-dependent activity; negative regulation of protein refolding; cellular response to tumor necrosis factor; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus;
	Sources:Amigo / QuickGO
Orthologs
	6625
	20637
	ENSG00000104852
	ENSMUSG00000063511
	P08621
	Q62376
	NM_001009820; NM_001301069; NM_003089
	NM_009224
	NP_001287998; NP_003080
	NP_033250
	Wikidata
View/Edit Human	View/Edit Mouse

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein^[5] that in humans is encoded by the SNRNP70 gene.^[6]^[7] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease.^[8]^[9] U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104852 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063511 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spritz RA, Strunk K, Surowy CS, Hoch SO, Barton DE, Francke U (December 1987). "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding". Nucleic Acids Research. 15 (24): 10373–91. doi:10.1093/nar/15.24.10373. PMC 339950. PMID 2447561.
^ "Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)".
^ Spritz RA, Strunk K, Surowy CS, Mohrenweiser HW (October 1990). "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3". Genomics. 8 (2): 371–9. doi:10.1016/0888-7543(90)90295-6. PMID 2147422.
^ Diner I, Hales CM, Bishof I, Rabenold L, Duong DM, Yi H, Laur O, Gearing M, Troncoso J, Thambisetty M, Lah JJ, Levey AI, Seyfried NT (December 2014). "Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease". The Journal of Biological Chemistry. 289 (51): 35296–313. doi:10.1074/jbc.M114.562959. PMC 4271217. PMID 25355317.
^ Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ (April 2014). "U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21". Molecular Neurodegeneration. 9: 15. doi:10.1186/1750-1326-9-15. PMC 4022210. PMID 24773620.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104852 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063511 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2447561-5] Spritz RA, Strunk K, Surowy CS, Hoch SO, Barton DE, Francke U (December 1987). "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding". Nucleic Acids Research. 15 (24): 10373–91. doi:10.1093/nar/15.24.10373. PMC 339950. PMID 2447561.

[6] "Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)".

[pmid2147422-7] Spritz RA, Strunk K, Surowy CS, Mohrenweiser HW (October 1990). "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3". Genomics. 8 (2): 371–9. doi:10.1016/0888-7543(90)90295-6. PMID 2147422.

[8] Diner I, Hales CM, Bishof I, Rabenold L, Duong DM, Yi H, Laur O, Gearing M, Troncoso J, Thambisetty M, Lah JJ, Levey AI, Seyfried NT (December 2014). "Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease". The Journal of Biological Chemistry. 289 (51): 35296–313. doi:10.1074/jbc.M114.562959. PMC 4271217. PMID 25355317.

[9] Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ (April 2014). "U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21". Molecular Neurodegeneration. 9: 15. doi:10.1186/1750-1326-9-15. PMC 4022210. PMID 24773620.

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