SPRY1 information

SPRY1
Identifiers
Aliases	SPRY1, hsprouty RTK signaling antagonist 1
External IDs	OMIM: 602465 MGI: 1345139 HomoloGene: 4266 GeneCards: SPRY1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	123,403,760 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	37,698,747 bp
RNA expression pattern
	Top expressed in
	pericardium; ; vena cava; ; gallbladder; ; parietal pleura; ; subcutaneous adipose tissue; ; canal of the cervix; ; left uterine tube; ; left lobe of thyroid gland; ; right coronary artery; ; left coronary artery;
	Top expressed in
	secondary oocyte; ; lip; ; lung; ; esophagus; ; quadriceps femoris muscle; ; zone of skin; ; adrenal gland; ; muscle tissue; ; lens; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi apparatus; membrane; plasma membrane; nucleoplasm; cytoplasm; cytosol;
Biological process	ureteric bud development; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; organ induction; bud elongation involved in lung branching; negative regulation of Ras protein signal transduction; multicellular organism development; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of GTPase activity; regulation of signal transduction; negative regulation of MAP kinase activity; establishment of mitotic spindle orientation; metanephros development; negative regulation of cell population proliferation; negative regulation of ERK1 and ERK2 cascade; epithelial to mesenchymal transition involved in cardiac fibroblast development;
	Sources:Amigo / QuickGO
Orthologs
	10252
	24063
	ENSG00000164056
	ENSMUSG00000037211
	O43609
	Q9QXV9
	NM_001258038; NM_001258039; NM_005841; NM_199327; NM_001375410
	NM_011896; NM_001305440; NM_001305441; NM_001305442
	NP_001244967; NP_001244968; NP_005832; NP_955359; NP_001362339
	NP_001292369; NP_001292370; NP_001292371; NP_036026
	Wikidata
View/Edit Human	View/Edit Mouse

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164056 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037211 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (January 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049. S2CID 498977.
^ Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I (July 2005). "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation". EMBO Reports. 6 (7): 635–41. doi:10.1038/sj.embor.7400453. PMC 1369112. PMID 15962011.
^ "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164056 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037211 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9458049-5] Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (January 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049. S2CID 498977.

[pmid15962011-6] Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I (July 2005). "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation". EMBO Reports. 6 (7): 635–41. doi:10.1038/sj.embor.7400453. PMC 1369112. PMID 15962011.

[entrez-7] "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)".

SPRY1 information

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