SNRPD3 information

SNRPD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D3B, 3CW1, 3PGW, 3VRI, 4PJO, 4WZJ, 3JCR
Identifiers
Aliases	SNRPD3, SMD3, Sm-D3, small nuclear ribonucleoprotein D3 polypeptide
External IDs	OMIM: 601062; MGI: 1914582; HomoloGene: 3078; GeneCards: SNRPD3; OMA:SNRPD3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,582,052 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,373,215 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; islet of Langerhans; ; ventricular zone; ; white blood cell; ; monocyte; ; appendix; ; muscle of thigh; ; granulocyte; ; olfactory zone of nasal mucosa; ; duodenum;
	Top expressed in
	abdominal wall; ; otic placode; ; ventricular zone; ; somite; ; migratory enteric neural crest cell; ; mandibular prominence; ; maxillary prominence; ; endocardial cushion; ; dermis; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone pre-mRNA DCP binding; U2 snRNA binding; protein binding; enzyme binding; U7 snRNA binding; telomerase RNA binding; U1 snRNP binding; RNA binding;
Cellular component	SMN-Sm protein complex; cytosol; prespliceosome; catalytic step 2 spliceosome; spliceosomal tri-snRNP complex; U5 snRNP; U12-type spliceosomal complex; U2 snRNP; nucleoplasm; methylosome; U7 snRNP; precatalytic spliceosome; small nuclear ribonucleoprotein complex; pICln-Sm protein complex; telomerase holoenzyme complex; spliceosomal complex; commitment complex; U4 snRNP; extracellular exosome; nucleus; U1 snRNP; cytoplasm; nuclear body; U4/U6 x U5 tri-snRNP complex; U2-type precatalytic spliceosome; U2-type catalytic step 2 spliceosome;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; RNA processing; mRNA processing; spliceosomal complex assembly; RNA splicing; histone mRNA metabolic process; protein methylation; import into nucleus; spliceosomal snRNP assembly;
	Sources:Amigo / QuickGO
Orthologs
	6634
	67332
	ENSG00000100028
	ENSMUSG00000020180
	P62318
	P62320
	NM_001278656; NM_004175
	NM_026095
	NP_001265585; NP_004166
	NP_080371
	Wikidata
View/Edit Human	View/Edit Mouse

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100028 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020180 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lehmeier T, Foulaki K, Lührmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240.
^ Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A. 91 (25): 12317–21. Bibcode:1994PNAS...9112317L. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560.
^ "Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100028 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020180 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1701240-5] Lehmeier T, Foulaki K, Lührmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240.

[pmid7527560-6] Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A. 91 (25): 12317–21. Bibcode:1994PNAS...9112317L. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560.

[entrez-7] "Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa".

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