DDX20 information

DDX20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OXC, 3B7G
Identifiers
Aliases	DDX20, DP103, GEMIN3, DEAD-box helicase 20
External IDs	OMIM: 606168; MGI: 1858415; HomoloGene: 5214; GeneCards: DDX20; OMA:DDX20 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	111,775,602 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	105,594,890 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; tibialis anterior muscle; ; secondary oocyte; ; testicle; ; gonad; ; pancreatic epithelial cell; ; mucosa of ileum; ; deltoid muscle;
	Top expressed in
	otic placode; ; otic vesicle; ; saccule; ; spermatid; ; seminiferous tubule; ; spermatocyte; ; epiblast; ; genital tubercle; ; maxillary prominence; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein-macromolecule adaptor activity; nucleotide binding; helicase activity; protein domain specific binding; histone deacetylase binding; protein binding; nucleic acid binding; hydrolase activity; ATP binding;
Cellular component	SMN-Sm protein complex; cytosol; membrane; transcription repressor complex; nucleoplasm; SMN complex; RNA polymerase II transcription repressor complex; cytoskeleton; nucleus; gemini of coiled bodies; cytoplasm; nuclear body; nucleolus;
Biological process	RNA processing; spliceosomal tri-snRNP complex assembly; mRNA processing; regulation of steroid biosynthetic process; negative regulation of transcription by RNA polymerase II; oogenesis; spliceosomal snRNP assembly; RNA secondary structure unwinding; RNA splicing; positive regulation of apoptotic process; negative regulation of transcription, DNA-templated; negative regulation of cell population proliferation; import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	11218
	53975
	ENSG00000064703
	ENSMUSG00000027905
	Q9UHI6
	Q9JJY4
	NM_007204
	NM_017397
	NP_009135
	NP_059093
	Wikidata
View/Edit Human	View/Edit Mouse

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064703 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027905 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grundhoff AT, Kremmer E, Türeci O, Glieden A, Gindorf C, Atz J, et al. (July 1999). "Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C". The Journal of Biological Chemistry. 274 (27): 19136–19144. doi:10.1074/jbc.274.27.19136. PMID 10383418.
^ "Entrez Gene: DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064703 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027905 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10383418-5] Grundhoff AT, Kremmer E, Türeci O, Glieden A, Gindorf C, Atz J, et al. (July 1999). "Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C". The Journal of Biological Chemistry. 274 (27): 19136–19144. doi:10.1074/jbc.274.27.19136. PMID 10383418.

[entrez-6] "Entrez Gene: DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20".

DDX20 information

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