membrane depolarization during Purkinje myocyte cell action potential
cardiac muscle contraction
regulation of sodium ion transport
sodium ion transport
regulation of atrial cardiac muscle cell membrane depolarization
membrane depolarization
regulation of ion transmembrane transport
cardiac muscle cell action potential involved in contraction
ion transport
cell adhesion
regulation of sodium ion transmembrane transporter activity
positive regulation of sodium ion transport
response to pyrethroid
regulation of heart rate by cardiac conduction
chemical synaptic transmission
corticospinal neuron axon guidance
neuronal action potential propagation
axon guidance
cardiac conduction
regulation of ventricular cardiac muscle cell membrane repolarization
sodium ion transmembrane transport
locomotion
positive regulation of neuron projection development
membrane depolarization during cardiac muscle cell action potential
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6324
20266
Ensembl
ENSG00000105711
ENSMUSG00000019194
UniProt
Q07699
P97952
RefSeq (mRNA)
NM_001037 NM_199037 NM_001321605
NM_011322
RefSeq (protein)
NP_001028 NP_001308534 NP_950238
NP_035452 NP_001389263
Location (UCSC)
Chr 19: 35.03 – 35.04 Mb
Chr 7: 30.82 – 30.83 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.[5][6]
Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM][6]
^ abcGRCh38: Ensembl release 89: ENSG00000105711 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000019194 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^McClatchey AI, Cannon SC, Slaugenhaupt SA, Gusella JF (Sep 1993). "The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain". Hum Mol Genet. 2 (6): 745–9. doi:10.1093/hmg/2.6.745. PMID 8394762.
^ ab"Entrez Gene: SCN1B sodium channel, voltage-gated, type I, beta".
Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Voltage-gated sodium channels are essential for the generation and...
that form part of the sodium channel, known as sodium channel β subunits (SCN1B, SCN2B, SCN3B) while others form different types of sodium channel (SCN10A)...
CACNA1C have been identified with LQT8. The sodium ion channel genes SCN1A, SCN1B, SCN2A, and SCN8A and the potassium channel KCNA1 have been implicated in...
there is likely a more polygenic cause of Dravet syndrome in these cases. - SCN1B: This gene encodes the beta-1 subunit of the sodium ion channel, which regulates...
of L1 CAMs. There are four distinct betas named in order of discovery: SCN1B, SCN2B, SCN3B, SCN4B (table 2). Beta 1 and beta 3 interact with the alpha...
are in the sodium channel α subunit genes SCN1A, an associated β subunit SCN1B, and in a GABAA receptor γ subunit gene, in GABRG2 and there is another...
compared to other mammalian species. It acts by binding to secreted FGF13A and SCN1B which leads to an inhibition of the voltage-gate sodium channels which generate...
the sodium channel α subunit genes SCN1A and SCN2A and the β subunit gene SCN1B. Mutations in the GABAA receptor γ subunit GABRG1 are also causative for...
function of the human cerebral cortex. LRRC37B binds to secreted FGF13A and SCN1B and modulate indirectly the activity of SCN8A, all involved in neural disorders...
2010). Of these, the 4 sodium channel beta-subunits, encoded by the genes SCN1B, SCN2B, SCN3B and SCN4B, form an important category. In general, beta-subunits...