SAV1 information

SAV1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DWV, 2YSB
Identifiers
Aliases	SAV1, SAV, WW45, WWP4, salvador family WW domain containing protein 1
External IDs	OMIM: 607203; MGI: 1927144; HomoloGene: 32517; GeneCards: SAV1; OMA:SAV1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	50,668,306 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	70,033,776 bp
RNA expression pattern
	Top expressed in
	oocyte; ; mucosa of paranasal sinus; ; secondary oocyte; ; nipple; ; lactiferous duct; ; olfactory zone of nasal mucosa; ; Achilles tendon; ; urethra; ; body of pancreas; ; superficial temporal artery;
	Top expressed in
	gastrula; ; spermatocyte; ; intercostal muscle; ; decidua; ; interventricular septum; ; calvaria; ; arm; ; upper arm; ; triceps brachii muscle; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular adaptor activity; identical protein binding;
Cellular component	cytoplasm; nucleus; cytosol; intracellular anatomical structure;
Biological process	hair follicle development; ventricular septum morphogenesis; lung epithelial cell differentiation; protein stabilization; positive regulation of DNA-binding transcription factor activity; regulation of stem cell population maintenance; negative regulation of cardiac muscle cell proliferation; regulation of organ growth; positive regulation of fat cell differentiation; hippo signaling; intestinal epithelial cell differentiation; signal transduction; keratinocyte differentiation; negative regulation of epithelial cell proliferation; positive regulation of apoptotic process; apoptotic process; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	60485
	64010
	ENSG00000151748
	ENSMUSG00000021067
	Q9H4B6
	Q8VEB2
	NM_021818
	NM_022028
	NP_068590
	NP_071311
	Wikidata
View/Edit Human	View/Edit Mouse

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.^[5]^[6]^[7]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021067 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK (Aug 2002). "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines". Cell. 110 (4): 467–78. doi:10.1016/S0092-8674(02)00824-3. PMID 12202036.
^ Valverde P (Oct 2000). "Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene". Biochem Biophys Res Commun. 276 (3): 990–8. doi:10.1006/bbrc.2000.3582. PMID 11027580. S2CID 22968498.
^ ^a ^b "SAV1 salvador family WW domain containing protein 1 [ Homo sapiens (human) ]".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151748 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021067 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12202036-5] Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK (Aug 2002). "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines". Cell. 110 (4): 467–78. doi:10.1016/S0092-8674(02)00824-3. PMID 12202036.

[pmid11027580-6] Valverde P (Oct 2000). "Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene". Biochem Biophys Res Commun. 276 (3): 990–8. doi:10.1006/bbrc.2000.3582. PMID 11027580. S2CID 22968498.

[entrez-7] "SAV1 salvador family WW domain containing protein 1 [ Homo sapiens (human) ]".

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