STK3 information

STK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WWS, 4HKD, 4L0N, 4LG4, 4LGD, 4OH9, 5BRM
Identifiers
Aliases	STK3, KRS1, MST2, serine/threonine kinase 3
External IDs	OMIM: 605030; MGI: 1928487; HomoloGene: 48420; GeneCards: STK3; OMA:STK3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	98,942,827 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	35,179,067 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tail of epididymis; ; caput epididymis; ; germinal epithelium; ; placenta; ; sural nerve; ; optic nerve; ; corpus epididymis; ; seminal vesicula; ; cartilage tissue;
	Top expressed in
	tail of embryo; ; dermis; ; pineal gland; ; Gonadal ridge; ; cumulus cell; ; blood; ; left lung lobe; ; zygote; ; abdominal wall; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein dimerization activity; protein serine/threonine kinase activator activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding; protein kinase activity; identical protein binding;
Cellular component	cytoplasm; cytosol; nucleus; protein-containing complex;
Biological process	regulation of cell differentiation involved in embryonic placenta development; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein kinase B signaling; intracellular signal transduction; phosphorylation; protein stabilization; positive regulation of DNA-binding transcription factor activity; positive regulation of JNK cascade; hippo signaling; endocardium development; protein phosphorylation; primitive hemopoiesis; central nervous system development; positive regulation of apoptotic process; positive regulation of protein binding; cell differentiation involved in embryonic placenta development; positive regulation of fat cell differentiation; negative regulation of organ growth; neural tube formation; negative regulation of canonical Wnt signaling pathway; signal transduction; negative regulation of cell population proliferation; hepatocyte apoptotic process; apoptotic process; positive regulation of protein serine/threonine kinase activity; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; regulation of apoptotic process; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	6788
	56274
	ENSG00000104375
	ENSMUSG00000022329
	Q13188
	Q9JI10
	NM_001256312; NM_001256313; NM_006281
	NM_019635; NM_001357821
	NP_001243241; NP_001243242; NP_006272
	NP_062609; NP_001344750
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104375 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022329 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taylor LK, Wang HC, Erikson RL (September 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proceedings of the National Academy of Sciences of the United States of America. 93 (19): 10099–104. Bibcode:1996PNAS...9310099T. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
^ "Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104375 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022329 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8816758-5] Taylor LK, Wang HC, Erikson RL (September 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proceedings of the National Academy of Sciences of the United States of America. 93 (19): 10099–104. Bibcode:1996PNAS...9310099T. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.

[entrez-6] "Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)".

STK3 information

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Protein kinase domain

WWTR1