protein serine/threonine kinase activator activity
metal ion binding
kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
magnesium ion binding
protein kinase activity
identical protein binding
Cellular component
cytoplasm
cytosol
nucleus
protein-containing complex
Biological process
regulation of cell differentiation involved in embryonic placenta development
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of protein kinase B signaling
intracellular signal transduction
phosphorylation
protein stabilization
positive regulation of DNA-binding transcription factor activity
positive regulation of JNK cascade
hippo signaling
endocardium development
protein phosphorylation
primitive hemopoiesis
central nervous system development
positive regulation of apoptotic process
positive regulation of protein binding
cell differentiation involved in embryonic placenta development
positive regulation of fat cell differentiation
negative regulation of organ growth
neural tube formation
negative regulation of canonical Wnt signaling pathway
signal transduction
negative regulation of cell population proliferation
hepatocyte apoptotic process
apoptotic process
positive regulation of protein serine/threonine kinase activity
regulation of mitotic cell cycle
stress-activated protein kinase signaling cascade
regulation of apoptotic process
activation of protein kinase activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6788
56274
Ensembl
ENSG00000104375
ENSMUSG00000022329
UniProt
Q13188
Q9JI10
RefSeq (mRNA)
NM_001256312 NM_001256313 NM_006281
NM_019635 NM_001357821
RefSeq (protein)
NP_001243241 NP_001243242 NP_006272
NP_062609 NP_001344750
Location (UCSC)
Chr 8: 98.37 – 98.94 Mb
Chr 15: 34.88 – 35.18 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000104375 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022329 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Taylor LK, Wang HC, Erikson RL (September 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proceedings of the National Academy of Sciences of the United States of America. 93 (19): 10099–104. Bibcode:1996PNAS...9310099T. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene. Protein kinase activation is a frequent response of cells to treatment...
genes. The serine/threonine kinase Hippo (Mst1/Mst2 encoded by the STK4 and STK3 genes respectively in mammals) activates a secondary kinase (Lats1/Lats2)...
protein is WWTR1. Also, the official names for MST1 and MST2 are STK4 and STK3, respectively. All databases for bioinformatics use the official gene symbols...
These include APC, CDKN1A, CDKN2A, CDKN2B, Ezrin, FGFR1, GADD45A, MGMT, STK3, STK4, PTEN, RASSF1A, WIF1, as well as several miRNAs. Expression of epigenetic...
signaling cascade, the core of which is made up of the serine-threonine kinases, STK3/MST2 and STK4/MST1, which when active and complexed with the regulatory protein...