Rex1 information

ZFP42
Identifiers
Aliases	ZFP42, REX1, ZNF754, REX-1, zfp-42, Rex1, ZFP42 zinc finger protein
External IDs	OMIM: 614572; MGI: 99187; HomoloGene: 7601; GeneCards: ZFP42; OMA:ZFP42 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	188,005,046 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	43,760,017 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; gonad; ; amniotic fluid; ; sperm; ; testicle; ; placenta; ; right testis; ; left testis; ; skin of thigh; ; ventricular zone;
	Top expressed in
	blastocyst; ; morula; ; placenta; ; spermatocyte; ; ureter; ; embryo; ; embryo; ; male human body; ; male reproductive system; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding;
Cellular component	cytoplasm; nucleus; transcription regulator complex; PcG protein complex;
Biological process	male gonad development; regulation of transcription, DNA-templated; transcription, DNA-templated; female gonad development; meiosis; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	132625
	22702
	ENSG00000179059
	ENSMUSG00000051176
	Q96MM3
	P22227
	NM_001304358; NM_174900
	NM_009556
	NP_001291287; NP_777560
	NP_033582
	Wikidata
View/Edit Human	View/Edit Mouse

Rex1 (Zfp-42) is a known marker of pluripotency, and is usually found in undifferentiated embryonic stem cells. In addition to being a marker for pluripotency, its regulation is also critical in maintaining a pluripotent state.^[5] As the cells begin to differentiate, Rex1 is severely and abruptly downregulated.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179059 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051176 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D (August 2006). "Regulation of the pluripotency marker Rex-1 by Nanog and Sox2". The Journal of Biological Chemistry. 281 (33): 23319–23325. doi:10.1074/jbc.M601811200. PMID 16714766.
^ Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH (November 2006). "A protein interaction network for pluripotency of embryonic stem cells". Nature. 444 (7117): 364–368. Bibcode:2006Natur.444..364W. doi:10.1038/nature05284. PMID 17093407. S2CID 4404796.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179059 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051176 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16714766-5] Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D (August 2006). "Regulation of the pluripotency marker Rex-1 by Nanog and Sox2". The Journal of Biological Chemistry. 281 (33): 23319–23325. doi:10.1074/jbc.M601811200. PMID 16714766.

[6] Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH (November 2006). "A protein interaction network for pluripotency of embryonic stem cells". Nature. 444 (7117): 364–368. Bibcode:2006Natur.444..364W. doi:10.1038/nature05284. PMID 17093407. S2CID 4404796.

Rex1 information

and 12 Related for: Rex1 information

Rex1

Homeobox protein NANOG

PREX1

Gq alpha subunit

Notch signaling pathway

Induced pluripotent stem cell

SOX2

Tbf5 protein domain

Tsix

Harmor

Owen Sansom

PREX2